Metalloproteases as potential therapeutic targets in arthritis treatment

Andrew D Rowan, Gary J Litherland, Wang Hui, Jennifer M Milner

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Dysregulated proteolysis of the extracellular matrix of articular cartilage represents a unifying hallmark of the arthritides, and has been a target for therapeutic intervention for some time, although clinical efficacy has been elusive. Members of the 'A disintegrin and metalloprotease with thrombospondin motifs' and matrix metalloprotease families are considered to be collectively responsible for cartilage catabolism, such that inhibition of these activities is theoretically a highly attractive strategy for preventing further proteolytic damage. This review outlines the biology of these metalloproteases and what we have learnt from inhibition studies and transgenics, and highlights the important questions that this information raises for the future development of therapeutics directed towards metalloproteases for arthritis treatment.

Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalExpert Opinion on Therapeutic Targets
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2008
Externally publishedYes

Keywords

  • Animals
  • Arthritis
  • Humans
  • Metalloproteases
  • Protease Inhibitors

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  • Research Output

    • 45 Citations
    • 10 Article
    • 3 Meeting Abstract

    Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes

    Baker, J., Falconer, A., Wilkinson, D. J., Europe-Finner, G. N., Litherland, G. & Rowan, A. D., 13 Apr 2018, In : PLoS ONE. 13, 4, 19 p., e0195864.

    Research output: Contribution to journalArticle

    Open Access
  • 9 Citations (Scopus)

    Cytokine-Induced MMP13 Expression in Human Chondrocytes is dependent on Activating Transcription Factor 3 (ATF3) regulation

    Chan, C. M., Macdonald, C. D., Litherland, G., Wilkinson, D. J., Skelton, A., Europe-Finner, G. N. & Rowan, A. D., 12 Dec 2016, In : Journal of Biological Chemistry.

    Research output: Contribution to journalArticle

    Open Access
  • 16 Citations (Scopus)

    Tribbles and arthritis: what are the links?

    Rowan, A. D. & Litherland, G. J., Oct 2015, In : Biochemical Society Transactions. 43, p. 1051-1056

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

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