Metabolic profiling and biological potential of the marine sponge associated Nocardiopsis sp. UR67 along with docking studies

Alyaa Hatem Ibrahim, Eman Zekry Attia, Heba A. Hofny, Faisal Alsenani, Ahmed Zayed, Mostafa E. Rateb, Usama Ramadan Abdelmohsen*, Samar Yehia Desoukey, Mostafa Ahmed Fouad, Mohamed Salah Kamel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This work was performed to dig into the phytochemical composition and bioactivities of Nocardiopsis sp. UR67 associated with the marine sponge Callyspongia sp. It was fermented in suspension and immobilised in calcium alginate bead cultures. The ethyl acetate extracts, afforded from the broth in each case named EG-49 and J-48g, respectively, revealed 16 chemical principles mostly belonging to polyketides, macrolides, and peptides. EG-49 and J-48g displayed anti-Candida albicans activity with IC50 values of 8.1 and 8.3 µg/mL, and a substantial cytotoxic effect against lung adenocarcinoma H1650 at IC50 12.6 and 13.7 µg/mL, respectively. However, only EG-49 exhibited a noteworthy anti-trypanosomal activity at 7.5 µg/mL. Molecular docking of the characterised compounds against Trypanosoma brucei trypanothione reductase demonstrated the highest binding models of griseochelin-methyl ester (9) and filipin-II (11), which drew considerable significance of the metabolites derived from Nocardiopsis sp. UR67 developing potential T. brucei trypanothione reductase inhibitors.
Original languageEnglish
Article number2084396
Number of pages7
JournalNatural Product Research
Early online date6 Jun 2022
DOIs
Publication statusE-pub ahead of print - 6 Jun 2022

Keywords

  • Nocardiopsis
  • marine sponges
  • metabolomics
  • anti-infective
  • cytotoxicity

Fingerprint

Dive into the research topics of 'Metabolic profiling and biological potential of the marine sponge associated Nocardiopsis sp. UR67 along with docking studies'. Together they form a unique fingerprint.

Cite this