Manipulation of the osteoblast response to a Ti-6Al-4V titanium alloy using a high power diode laser

L. Hao, J. Lawrence, L Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


To improve the bone integration of titanium-based implants a high power diode laser (HPDL) was used to modify the material for improved osteoblast cell response. The surface properties of un-treated and HPDL treated samples were characterized. Contact angles for the un-treated and the HPDL modified titanium alloy (Ti-6Al-4V) were determined with selected biological liquids by the sessile drop technique. The analysis revealed that the wettability of the Ti-6Al-4V improved after HPDL laser treatment, indicating that better interaction with the biological liquids occurred. Moreover, an in vitro human fetal osteoblast cells (hFOB 1.19) evaluation revealed a more favourable cell response on the HPDL laser treated Ti-6Al-4V alloy than on either un-treated sample or a mechanically roughened sample. It was consequently determined that the HPDL provides more a controllable and effective technique to improve the biocompatibility of bio-metals.
Original languageEnglish
Pages (from-to)602-606
Number of pages5
JournalApplied Surface Science
Issue number1-4
Early online date10 Mar 2005
Publication statusPublished - 15 Jul 2005
Externally publishedYes


  • high power diode laser
  • osteoblast cell
  • titanium alloy
  • wettability


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