Macrophage dysfunction in Psoriatic Arthritis

Mark H. Wenink; Kim CM Santegoets; Lenny van Bon; John Butcher; Wim B. van den Berg; Piet LCM van Riel; Iain B. McInnes; Timothy RDJ Radstake

doi:10.1186/1479-5876-9-S2-P59

Macrophage dysfunction in Psoriatic Arthritis

Mark H. Wenink, Kim CM Santegoets, Lenny van Bon, John Butcher, Wim B. van den Berg, Piet LCM van Riel, Iain B. McInnes, Timothy RDJ Radstake

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

The pathogenesis of Psoriatic Arthritis (PsA) remains poorly understood. The underlying chronic inflammatory immune response is thought to be triggered by unknown environmental factors and might arise due to an impaired (innate) immune function by Dendritic Cells (DCs) [1]. Anti-inflammatory CD163+ type 2 macrophages (mf-2) are thought to have important functions in restoring immune homeostasis during an inflammatory response. Mf-2 are present in PsA synovium at high numbers. Why the immune response in PsA goes awry, despite the presence of these mf-2, is still largely undetermined.

Original language	English
Article number	P59
Journal	Journal of Translational Medicine
Volume	9
Issue number	2
DOIs	https://doi.org/10.1186/1479-5876-9-S2-P59
Publication status	Published - 23 Nov 2011
Externally published	Yes
Event	6th European Workshop on Immune-Mediated Inflammatory Diseases - Nice, France Duration: 23 Nov 2011 → 25 Nov 2011

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title = "Macrophage dysfunction in Psoriatic Arthritis",

abstract = "The pathogenesis of Psoriatic Arthritis (PsA) remains poorly understood. The underlying chronic inflammatory immune response is thought to be triggered by unknown environmental factors and might arise due to an impaired (innate) immune function by Dendritic Cells (DCs) [1]. Anti-inflammatory CD163+ type 2 macrophages (mf-2) are thought to have important functions in restoring immune homeostasis during an inflammatory response. Mf-2 are present in PsA synovium at high numbers. Why the immune response in PsA goes awry, despite the presence of these mf-2, is still largely undetermined.",

author = "Wenink, {Mark H.} and Santegoets, {Kim CM} and {van Bon}, Lenny and John Butcher and {van den Berg}, {Wim B.} and {van Riel}, {Piet LCM} and McInnes, {Iain B.} and Radstake, {Timothy RDJ}",

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doi = "10.1186/1479-5876-9-S2-P59",

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TY - JOUR

T1 - Macrophage dysfunction in Psoriatic Arthritis

AU - Wenink, Mark H.

AU - Santegoets, Kim CM

AU - van Bon, Lenny

AU - Butcher, John

AU - van den Berg, Wim B.

AU - van Riel, Piet LCM

AU - McInnes, Iain B.

AU - Radstake, Timothy RDJ

PY - 2011/11/23

Y1 - 2011/11/23

N2 - The pathogenesis of Psoriatic Arthritis (PsA) remains poorly understood. The underlying chronic inflammatory immune response is thought to be triggered by unknown environmental factors and might arise due to an impaired (innate) immune function by Dendritic Cells (DCs) [1]. Anti-inflammatory CD163+ type 2 macrophages (mf-2) are thought to have important functions in restoring immune homeostasis during an inflammatory response. Mf-2 are present in PsA synovium at high numbers. Why the immune response in PsA goes awry, despite the presence of these mf-2, is still largely undetermined.

AB - The pathogenesis of Psoriatic Arthritis (PsA) remains poorly understood. The underlying chronic inflammatory immune response is thought to be triggered by unknown environmental factors and might arise due to an impaired (innate) immune function by Dendritic Cells (DCs) [1]. Anti-inflammatory CD163+ type 2 macrophages (mf-2) are thought to have important functions in restoring immune homeostasis during an inflammatory response. Mf-2 are present in PsA synovium at high numbers. Why the immune response in PsA goes awry, despite the presence of these mf-2, is still largely undetermined.

U2 - 10.1186/1479-5876-9-S2-P59

DO - 10.1186/1479-5876-9-S2-P59

M3 - Meeting Abstract

SN - 1479-5876

VL - 9

JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

IS - 2

M1 - P59

T2 - 6th European Workshop on Immune-Mediated Inflammatory Diseases

Y2 - 23 November 2011 through 25 November 2011

ER -

Macrophage dysfunction in Psoriatic Arthritis

Abstract

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