Long-term effects of high intensity resistance and endurance exercise on plasma leptin and ghrelin in overweight individuals: the RESOLVE Study

Angelo Tremblay, Frédéric Dutheil, Vicky Drapeau, Lore Metz, Bruno Lesourd, Robert Chapier, Bruno Pereira, Julien Verney, Julien S. Baker, Agnes Vinet, Guillaume Walther, Philippe Obert, Daniel Courteix, David Thivel

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Abstract

The objective of this study was to evaluate the effects of high-intensity resistance and endurance exercise on body composition and plasma leptin and ghrelin concentrations in overweight individuals. One hundred participants were randomly assigned to 3 exercise interventions: high-resistance-low-aerobic exercise (Re), low-resistance-high-aerobic exercise (rE), low-resistance-low-aerobic exercise (re). Interventions began with 3 weeks of residential supervision (phase 1) after which participants had to manage the physical activity programs individually (phase 2). Body composition and plasma variables were measured at baseline and after phase 1 as well as after 3, 6, and 12 months. Significant decreases in body weight and fat were observed after phase 1 ( p < 0.001) and continued at a lower rate for up to 3 months and then remained stable for the rest of the protocol. Once a body weight plateau was reached, body fat loss after the Re and rE conditions exceeded the fat loss observed in the re condition by 1.5-2 kg ( p < 0.05). Leptin was significantly decreased after day 21 and month 3 ( p < 0.001) and remained stable for the rest of the study. Ghrelin was significantly increased after day 21 and month 3 ( p < 0.001) and returned to a level comparable to baseline between month 6 and 12 when body weight and fat had reached a plateau. In conclusion, this study reinforces the idea that an increase in exercise intensity may accentuate body fat loss before the occurrence of a body weight plateau. Resistance to further fat loss was accompanied by a decrease in plasma leptin and an increase in plasma ghrelin.

Original languageEnglish
Pages (from-to)1172-1179
Number of pages8
JournalApplied Physiology, Nutrition, and Metabolism
Volume44
Issue number11
Early online date15 Mar 2019
DOIs
Publication statusPublished - Nov 2019

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Ghrelin
Leptin
Adipose Tissue
Body Weight
Exercise
Body Composition
Fats

Keywords

  • Obesity
  • Physical activity
  • Energy
  • Appetite
  • Hormones
  • Fat

Cite this

Tremblay, Angelo ; Dutheil, Frédéric ; Drapeau, Vicky ; Metz, Lore ; Lesourd, Bruno ; Chapier, Robert ; Pereira, Bruno ; Verney, Julien ; Baker, Julien S. ; Vinet, Agnes ; Walther, Guillaume ; Obert, Philippe ; Courteix, Daniel ; Thivel, David. / Long-term effects of high intensity resistance and endurance exercise on plasma leptin and ghrelin in overweight individuals : the RESOLVE Study. In: Applied Physiology, Nutrition, and Metabolism. 2019 ; Vol. 44, No. 11. pp. 1172-1179.
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abstract = "The objective of this study was to evaluate the effects of high-intensity resistance and endurance exercise on body composition and plasma leptin and ghrelin concentrations in overweight individuals. One hundred participants were randomly assigned to 3 exercise interventions: high-resistance-low-aerobic exercise (Re), low-resistance-high-aerobic exercise (rE), low-resistance-low-aerobic exercise (re). Interventions began with 3 weeks of residential supervision (phase 1) after which participants had to manage the physical activity programs individually (phase 2). Body composition and plasma variables were measured at baseline and after phase 1 as well as after 3, 6, and 12 months. Significant decreases in body weight and fat were observed after phase 1 ( p < 0.001) and continued at a lower rate for up to 3 months and then remained stable for the rest of the protocol. Once a body weight plateau was reached, body fat loss after the Re and rE conditions exceeded the fat loss observed in the re condition by 1.5-2 kg ( p < 0.05). Leptin was significantly decreased after day 21 and month 3 ( p < 0.001) and remained stable for the rest of the study. Ghrelin was significantly increased after day 21 and month 3 ( p < 0.001) and returned to a level comparable to baseline between month 6 and 12 when body weight and fat had reached a plateau. In conclusion, this study reinforces the idea that an increase in exercise intensity may accentuate body fat loss before the occurrence of a body weight plateau. Resistance to further fat loss was accompanied by a decrease in plasma leptin and an increase in plasma ghrelin.",
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Tremblay, A, Dutheil, F, Drapeau, V, Metz, L, Lesourd, B, Chapier, R, Pereira, B, Verney, J, Baker, JS, Vinet, A, Walther, G, Obert, P, Courteix, D & Thivel, D 2019, 'Long-term effects of high intensity resistance and endurance exercise on plasma leptin and ghrelin in overweight individuals: the RESOLVE Study', Applied Physiology, Nutrition, and Metabolism, vol. 44, no. 11, pp. 1172-1179. https://doi.org/10.1139/apnm-2019-0019

Long-term effects of high intensity resistance and endurance exercise on plasma leptin and ghrelin in overweight individuals : the RESOLVE Study. / Tremblay, Angelo; Dutheil, Frédéric; Drapeau, Vicky; Metz, Lore; Lesourd, Bruno; Chapier, Robert; Pereira, Bruno; Verney, Julien; Baker, Julien S.; Vinet, Agnes; Walther, Guillaume; Obert, Philippe; Courteix, Daniel; Thivel, David.

In: Applied Physiology, Nutrition, and Metabolism, Vol. 44, No. 11, 11.2019, p. 1172-1179.

Research output: Contribution to journalArticle

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T1 - Long-term effects of high intensity resistance and endurance exercise on plasma leptin and ghrelin in overweight individuals

T2 - the RESOLVE Study

AU - Tremblay, Angelo

AU - Dutheil, Frédéric

AU - Drapeau, Vicky

AU - Metz, Lore

AU - Lesourd, Bruno

AU - Chapier, Robert

AU - Pereira, Bruno

AU - Verney, Julien

AU - Baker, Julien S.

AU - Vinet, Agnes

AU - Walther, Guillaume

AU - Obert, Philippe

AU - Courteix, Daniel

AU - Thivel, David

PY - 2019/11

Y1 - 2019/11

N2 - The objective of this study was to evaluate the effects of high-intensity resistance and endurance exercise on body composition and plasma leptin and ghrelin concentrations in overweight individuals. One hundred participants were randomly assigned to 3 exercise interventions: high-resistance-low-aerobic exercise (Re), low-resistance-high-aerobic exercise (rE), low-resistance-low-aerobic exercise (re). Interventions began with 3 weeks of residential supervision (phase 1) after which participants had to manage the physical activity programs individually (phase 2). Body composition and plasma variables were measured at baseline and after phase 1 as well as after 3, 6, and 12 months. Significant decreases in body weight and fat were observed after phase 1 ( p < 0.001) and continued at a lower rate for up to 3 months and then remained stable for the rest of the protocol. Once a body weight plateau was reached, body fat loss after the Re and rE conditions exceeded the fat loss observed in the re condition by 1.5-2 kg ( p < 0.05). Leptin was significantly decreased after day 21 and month 3 ( p < 0.001) and remained stable for the rest of the study. Ghrelin was significantly increased after day 21 and month 3 ( p < 0.001) and returned to a level comparable to baseline between month 6 and 12 when body weight and fat had reached a plateau. In conclusion, this study reinforces the idea that an increase in exercise intensity may accentuate body fat loss before the occurrence of a body weight plateau. Resistance to further fat loss was accompanied by a decrease in plasma leptin and an increase in plasma ghrelin.

AB - The objective of this study was to evaluate the effects of high-intensity resistance and endurance exercise on body composition and plasma leptin and ghrelin concentrations in overweight individuals. One hundred participants were randomly assigned to 3 exercise interventions: high-resistance-low-aerobic exercise (Re), low-resistance-high-aerobic exercise (rE), low-resistance-low-aerobic exercise (re). Interventions began with 3 weeks of residential supervision (phase 1) after which participants had to manage the physical activity programs individually (phase 2). Body composition and plasma variables were measured at baseline and after phase 1 as well as after 3, 6, and 12 months. Significant decreases in body weight and fat were observed after phase 1 ( p < 0.001) and continued at a lower rate for up to 3 months and then remained stable for the rest of the protocol. Once a body weight plateau was reached, body fat loss after the Re and rE conditions exceeded the fat loss observed in the re condition by 1.5-2 kg ( p < 0.05). Leptin was significantly decreased after day 21 and month 3 ( p < 0.001) and remained stable for the rest of the study. Ghrelin was significantly increased after day 21 and month 3 ( p < 0.001) and returned to a level comparable to baseline between month 6 and 12 when body weight and fat had reached a plateau. In conclusion, this study reinforces the idea that an increase in exercise intensity may accentuate body fat loss before the occurrence of a body weight plateau. Resistance to further fat loss was accompanied by a decrease in plasma leptin and an increase in plasma ghrelin.

KW - Obesity

KW - Physical activity

KW - Energy

KW - Appetite

KW - Hormones

KW - Fat

U2 - 10.1139/apnm-2019-0019

DO - 10.1139/apnm-2019-0019

M3 - Article

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JO - Applied Physiology, Nutrition, and Metabolism

JF - Applied Physiology, Nutrition, and Metabolism

SN - 1715-5312

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