Liposomal amphotericin B displays rapid dose-dependent activity against Candida albicans biofilms

Gordon Ramage; Anto Jose; Leighann Sherry; David F Lappin; Brian Jones; Craig Williams

doi:10.1128/AAC.02344-12

Liposomal amphotericin B displays rapid dose-dependent activity against Candida albicans biofilms

Gordon Ramage
, Anto Jose
, Leighann Sherry
, David F Lappin
, Brian Jones
, Craig Williams

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration-dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.

Original language	English
Pages (from-to)	2369-2371
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	5
DOIs	https://doi.org/10.1128/AAC.02344-12
Publication status	Published - May 2013

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title = "Liposomal amphotericin B displays rapid dose-dependent activity against Candida albicans biofilms",

abstract = "Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90\%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration-dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.",

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AU - Ramage, Gordon

AU - Jose, Anto

AU - Sherry, Leighann

AU - Lappin, David F

AU - Jones, Brian

AU - Williams, Craig

PY - 2013/5

Y1 - 2013/5

N2 - Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration-dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.

AB - Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration-dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.

U2 - 10.1128/AAC.02344-12

DO - 10.1128/AAC.02344-12

M3 - Article

SN - 0066-4804

VL - 57

SP - 2369

EP - 2371

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Liposomal amphotericin B displays rapid dose-dependent activity against Candida albicans biofilms

Abstract

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