Liposomal amphotericin B displays rapid dose-dependent activity against Candida albicans biofilms

Gordon Ramage, Anto Jose, Leighann Sherry, David F Lappin, Brian Jones, Craig Williams

Research output: Contribution to journalArticle

Abstract

Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration-dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.
Original languageEnglish
Pages (from-to)2369-2371
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number5
DOIs
Publication statusPublished - May 2013

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Biofilms
caspofungin
Candida albicans
Catheters
Antifungal Agents
Amphotericin B
liposomal amphotericin B
Therapeutics

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Ramage, Gordon ; Jose, Anto ; Sherry, Leighann ; Lappin, David F ; Jones, Brian ; Williams, Craig. / Liposomal amphotericin B displays rapid dose-dependent activity against Candida albicans biofilms. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 5. pp. 2369-2371.
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Liposomal amphotericin B displays rapid dose-dependent activity against Candida albicans biofilms. / Ramage, Gordon; Jose, Anto; Sherry, Leighann; Lappin, David F; Jones, Brian; Williams, Craig.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 5, 05.2013, p. 2369-2371.

Research output: Contribution to journalArticle

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AU - Jose, Anto

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AU - Lappin, David F

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AU - Williams, Craig

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M3 - Article

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JF - Antimicrobial Agents and Chemotherapy

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