Liposomal amphotericin B displays rapid dose-dependent activity against Candida albicans biofilms

Gordon Ramage, Anto Jose, Leighann Sherry, David F Lappin, Brian Jones, Craig Williams

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration-dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.
Original languageEnglish
Pages (from-to)2369-2371
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number5
DOIs
Publication statusPublished - May 2013

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