Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

Keyphrases

• Matrix Metalloproteinases 100%
• White Adipose Tissue 100%
• Cartilage Degeneration 100%
• Leptin 100%
• Collagen 41%
• Matrix Metalloproteinase 13 (MMP13) 33%
• Cartilage 33%
• Interleukin-1β 25%
• Matrix metalloproteinase-1 (MMP-1) 25%
• Chondrocytes 25%
• Bovine Articular Cartilage 16%
• Collagenolytic Activity 16%
• Infrapatellar Fat Pad 16%
• Gelatinolytic Activity 16%
• Osteoarthritis 16%
• Culture Supernatant 8%
• Immunoassay 8%
• Fat Pad 8%
• JNK Inhibitor 8%
• Cartilage Destruction 8%
• Peri 8%
• Gelatin Zymography 8%
• Proteolytic Enzymes 8%
• Supernatant 8%
• NF-B 8%
• Leptin Levels 8%
• Cartilage Metabolism 8%
• Real-time RT-PCR 8%
• Signaling Pathway Activation 8%
• Selective Inhibitor 8%
• Mapk 8%
• Proinflammatory Stimuli 8%
• Obesity 8%
• Explant Culture 8%
• Signaling Pathway 8%
• Pro-inflammatory Adipokines 8%
• Catabolism 8%
• Immunoblotting 8%
• Catabolic 8%
• Inflammatory Process 8%
• Knee Osteoarthritis 8%
• Cartilage Explants 8%
• Conditioned Medium 8%
• Knee Joint 8%
• Phosphoinositide 3-kinase (PI3K) 8%
• Degenerative Process 8%
• Local Producers 8%

Medicine and Dentistry

• Chondrocyte 23%
• Protein Kinase B 15%