Laser surface engineering of polymeric materials for enhanced mesenchymal stem cell adhesion and growth

D.G. Waugh*, D. Cosgrove, I. Hussain, J. Lawrence

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Owing to them being relatively inexpensive and easy to manipulate, polymers are becoming more widely used within the biomedical industry for several different applications. As an example, because of its high wear resistance, low moisture absorption and high chemical resistance, poly(ether ether ketone) is commonly used as a biomaterial in the healthcare and biomedical industries. However, poly(ether ether ketone) surface properties are not optimum for efficient or enhanced bio-functionality, leading it to have somewhat inferior wettability and adhesion characteristics. On account of this, many researchers are now looking to employ surface engineering techniques to improve and enhance the surface properties of poly(ether ether ketone), enhancing its biomimetic nature and improving the bio-adhesion properties. This chapter discusses the importance of Mesenchymal Stem Cells (MSCs), the biological applications of poly(ether ether ketone) and the application of lasers for surface engineering of poly(ether ether ketone) for modifying mesenchymal stem cell response. Through the application of CO2 laser surface engineering it has been shown that laser surface engineering can have a positive effect on the rate of human mesenchymal cell growth, highlighting the opportunities for the healthcare and biomedical industries to adopt such technique. In addition, discussion of including poly(ether ether ketone) and other polymer materials as bio-composite materials for future research is introduced for enhancing material properties.
Original languageEnglish
Title of host publicationAdvances in Contact Angle, Wettability and Adhesion
EditorsK.L. Mittal
Place of PublicationUnited States
PublisherScrivener Publishing
Chapter13
Pages267-297
Number of pages31
Volume4
ISBN (Electronic)9781119593294
ISBN (Print)9781119592549
DOIs
Publication statusPublished - 18 Oct 2019
Externally publishedYes

Keywords

  • mesenchymal stem cells
  • poly(ether ether ketone)
  • surface modification
  • bio-engineering
  • laser treatment
  • polymeric biomaterials
  • surface engineering

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