Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

Dominik Wichner; Hamidah Idris; Wael E.  Houssen; Andrew R. McEwan; Alan T. Bull; Juan A Asenjo; Michael Goodfellow; Marcel Jaspars; Rainer Ebel; Mostafa Rateb

doi:10.1038/ja.2016.78

Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

Dominik Wichner
, Hamidah Idris
, Wael E. Houssen
, Andrew R. McEwan
, Alan T. Bull
, Juan A Asenjo
, Michael Goodfellow
, Marcel Jaspars
, Rainer Ebel
, Mostafa Rateb^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

155 Downloads (Pure)

Abstract

The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.

Original language	English
Pages (from-to)	448-453
Number of pages	6
Journal	The Journal of Antibiotics
Volume	70
Issue number	4
Early online date	29 Jun 2016
DOIs	https://doi.org/10.1038/ja.2016.78
Publication status	E-pub ahead of print - 29 Jun 2016

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SDG 3 Good Health and Well-being

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2016 05 31 Wichner et al Isolation acceptedAccepted author manuscript, 736 KB

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Wichner, D., Idris, H., Houssen, W. E., McEwan, A. R., Bull, A. T., A Asenjo, J., Goodfellow, M., Jaspars, M., Ebel, R., & Rateb, M. (2016). Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil. The Journal of Antibiotics, 70(4), 448-453. Advance online publication. https://doi.org/10.1038/ja.2016.78

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title = "Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil",

abstract = "The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.",

author = "Dominik Wichner and Hamidah Idris and Houssen, \{Wael E.\} and McEwan, \{Andrew R.\} and Bull, \{Alan T.\} and \{A Asenjo\}, Juan and Michael Goodfellow and Marcel Jaspars and Rainer Ebel and Mostafa Rateb",

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Wichner, D, Idris, H, Houssen, WE, McEwan, AR, Bull, AT, A Asenjo, J, Goodfellow, M, Jaspars, M, Ebel, R & Rateb, M 2016, 'Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil', The Journal of Antibiotics, vol. 70, no. 4, pp. 448-453. https://doi.org/10.1038/ja.2016.78

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T1 - Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

AU - Wichner, Dominik

AU - Idris, Hamidah

AU - Houssen, Wael E.

AU - McEwan, Andrew R.

AU - Bull, Alan T.

AU - A Asenjo, Juan

AU - Goodfellow, Michael

AU - Jaspars, Marcel

AU - Ebel, Rainer

AU - Rateb, Mostafa

PY - 2016/6/29

Y1 - 2016/6/29

N2 - The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.

AB - The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.

U2 - 10.1038/ja.2016.78

DO - 10.1038/ja.2016.78

M3 - Article

SN - 0021-8820

VL - 70

SP - 448

EP - 453

JO - The Journal of Antibiotics

JF - The Journal of Antibiotics

IS - 4

ER -

Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

Abstract

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