Investigation of novel polymorphisms within the 3' region of the IL-6 gene in patients with rheumatoid arthritis using Genescan analysis

Anne Crilly, John M.S. Bartlett, Anne White, David Stirling, Hilary Capell, Rajan Madhok

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A highly polymorphic AT rich repeat exists in the 3' flanking region of the IL-6 gene. Using Genescan analysis we studied this region of the IL-6 gene in 55 normals and 95 patients with rheumatoid arthritis (RA). The influence of alleles on need for early major joint surgery in RA patients was assessed. We identified nine alleles of which, G8, G7 and G4 were the most common (37% vs 36% vs 13%). RA surgery patients had an increase in the frequency of G7 compared to non-surgery and control populations (46% vs 27% vs 34%, respectively) and a decrease in G8 (22% vs 46% vs 43%, respectively). RA patients homozygous for G8 had a lower ESR than those homozygous for G7 (23 mm/h vs 36 mm/h) although this was not significant. We have determined these alleles and their distribution in a normal and RA population. Initial findings suggest G8 may be associated with lower erythrocyte sedimentation rate (ESR) and less severe RA. Although trends in allele distribution were observed, further studies in larger cohorts are required.

Original languageEnglish
Pages (from-to)109-12
Number of pages4
JournalCytokine
Volume13
Issue number2
DOIs
Publication statusPublished - Jan 2001
Externally publishedYes

Keywords

  • Alleles
  • Arthritis, Rheumatoid
  • Blood Sedimentation
  • Genotype
  • Homozygote
  • Humans
  • Interleukin-6
  • Polymorphism, Genetic
  • Statistics as Topic
  • Genescan

Fingerprint Dive into the research topics of 'Investigation of novel polymorphisms within the 3' region of the IL-6 gene in patients with rheumatoid arthritis using Genescan analysis'. Together they form a unique fingerprint.

Cite this