Implications of antimicrobial combinations in complex wound biofilms containing fungi

Eleanor M Townsend, Leighann Sherry, Ryan Kean, Donald Hansom, William G Mackay, Craig Williams, John Butcher, Gordon Ramage

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Abstract

Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while mono-treatment approaches influenced biofilm composition it had no discernible effect on overall quantity. Only by combining bacterial and fungal specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.
Original languageEnglish
Article numbere00672-17
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number9
Early online date10 Jul 2017
DOIs
Publication statusPublished - 1 Sep 2017

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Keywords

  • Biofilm
  • Polymicrobial
  • Chronic wound
  • Antimicrobial
  • Candida

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