Immunomodulation by the female sex hormones

Research output: Contribution to journalArticle

Abstract

Pregnancy is a highly regulated process, requiring strict control of the immune system in order to prevent rejection of the semiallogenic foetus. One aspect of pregnancy immunology that has been of great interest is the influence of female sex and pregnancy associated hormones, such as progesterone and oestrogen, on cells of the immune system.

This review evaluates studies investigating the ability of these hormones to modulate the function of cells of both the innate and adaptive arms of the immune system and mechanisms by which immunity to infection can be altered due to increased levels of progesterone and oestrogen. Finally, the influence of pregnancy on the most common autoimmune diseases, on toxoplasmosis and on malaria is reviewed.
Original languageEnglish
Pages (from-to)61-72
JournalOpen Infectious Diseases Journal
Volume3
DOIs
Publication statusPublished - 23 Jun 2009

Fingerprint

Immunomodulation
Gonadal Steroid Hormones
Immune System
Pregnancy
Progesterone
Estrogens
Hormones
Toxoplasmosis
Allergy and Immunology
Autoimmune Diseases
Malaria
Immunity
Fetus
Infection

Keywords

  • immunology
  • progesterone
  • estrogen
  • sex hormones

Cite this

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title = "Immunomodulation by the female sex hormones",
abstract = "Pregnancy is a highly regulated process, requiring strict control of the immune system in order to prevent rejection of the semiallogenic foetus. One aspect of pregnancy immunology that has been of great interest is the influence of female sex and pregnancy associated hormones, such as progesterone and oestrogen, on cells of the immune system.This review evaluates studies investigating the ability of these hormones to modulate the function of cells of both the innate and adaptive arms of the immune system and mechanisms by which immunity to infection can be altered due to increased levels of progesterone and oestrogen. Finally, the influence of pregnancy on the most common autoimmune diseases, on toxoplasmosis and on malaria is reviewed.",
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Immunomodulation by the female sex hormones. / Menzies, Fiona; Henriquez, Fiona.

In: Open Infectious Diseases Journal, Vol. 3, 23.06.2009, p. 61-72.

Research output: Contribution to journalArticle

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KW - estrogen

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