Immunogenetics of Toxoplasma gondii informs vaccine design

Fiona Henriquez-Mui, Stuart Woods, Hua Cong, Rima McLeod, Craig W. Roberts

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

A series of studies over 20 years mapped resistance to toxoplasmic encephalitis in mice to major histocompatibility complex class I (MHC I) and ultimately, more precisely the Ld region This is consistent with contemporary functional studies that demonstrated a protective role for CD8(+) T cells Recent studies have demonstrated that the Ld gene product presents a number of immunodominant Toxoplasma gondii-derived peptides in the murine models, providing a paradigm for vaccine design The almost complete sequencing of the genomes of the predominant strains of T gondii in conjunction with the development of predictive binding algorithms for MHC I peptides in humans now offers a new opportunity for vaccine development against this medically important pathogen
Original languageEnglish
Pages (from-to)550-555
JournalTrends in Parasitology
Volume26
Issue number11
DOIs
Publication statusPublished - Nov 2010

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