IGF-binding protein 1 and abdominal obesity in the development of type 2 diabetes in women

Moira Lewitt, Agneta Hilding, Kerstin Brismar, Suad Efendic, Claes-Göran Östenson, Kerstin Hall

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Low levels of IGF-binding protein 1 (IGFBP1) are associated with metabolic syndrome and predict diabetes development in men. The aim of this study was to determine the levels of IGFBP1 in women who later develop diabetes, in relation to abdominal obesity, and to compare these levels with those of men. METHODS: IGFBP1 levels were determined at baseline and after 8 years in a case-control, prospective study of Swedish women aged 35-56 years. Individuals with normal oral glucose tolerance test (OGTT) who developed abnormal glucose regulation (n=240) were pair matched to controls for age and family history of diabetes and also compared to men of the same age (n=355). RESULTS: Low fasting IGFBP1 and increased waist measurement predicted development of diabetes in women (n=60; odds ratio (OR) 70, 95% confidence interval (CI) 8-661, lowest tertile and OR 27, 95% CI 5-141, highest tertile). In women developing diabetes, baseline IGFBP1 levels were lower than expected for fasting insulin values, were associated with impaired suppression after OGTT and increased during 8 years despite an increase in fasting insulin. All individuals in the highest tertile for waist and with <or=40% suppression of IGFBP1 developed diabetes within 8 years. Circulating IGFBP1 concentrations were higher in women compared to men. Women and men who developed diabetes had a similar degree of abdominal obesity, corrected for height. CONCLUSIONS: We conclude that low IGFBP1 and elevated waist measurement predict diabetes development and that IGFBP1 production is suppressed by a novel factor(s) in women developing diabetes. Increasing levels of IGFBP1 during the emergence of diabetes in men and women suggest the emergence of hepatic insulin resistance.
Original languageEnglish
Pages (from-to)233-242
Number of pages10
JournalEuropean Journal of Endocrinology
Volume163
Issue number2
DOIs
Publication statusPublished - 2010

Fingerprint

Insulin-Like Growth Factor Binding Protein 1
Abdominal Obesity
Type 2 Diabetes Mellitus
Fasting
Glucose Tolerance Test
Odds Ratio
Confidence Intervals
Insulin
Insulin Resistance
Case-Control Studies
Prospective Studies

Keywords

  • Adult
  • Case-Control Studies
  • Diabetes Mellitus, Type 2/*metabolism
  • Female
  • Glucose Tolerance Test
  • Humans
  • Insulin/blood
  • Insulin-Like Growth Factor Binding Protein 1/*metabolism
  • Insulin-Like Growth Factor I/metabolism
  • Middle Aged
  • Obesity, Abdominal/*metabolism
  • Odds Ratio
  • Prospective Studies
  • Radioimmunoassay
  • Regression Analysis
  • Sweden
  • Waist Circumference

Cite this

Lewitt, Moira ; Hilding, Agneta ; Brismar, Kerstin ; Efendic, Suad ; Östenson, Claes-Göran ; Hall, Kerstin. / IGF-binding protein 1 and abdominal obesity in the development of type 2 diabetes in women. In: European Journal of Endocrinology. 2010 ; Vol. 163, No. 2. pp. 233-242.
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abstract = "OBJECTIVE: Low levels of IGF-binding protein 1 (IGFBP1) are associated with metabolic syndrome and predict diabetes development in men. The aim of this study was to determine the levels of IGFBP1 in women who later develop diabetes, in relation to abdominal obesity, and to compare these levels with those of men. METHODS: IGFBP1 levels were determined at baseline and after 8 years in a case-control, prospective study of Swedish women aged 35-56 years. Individuals with normal oral glucose tolerance test (OGTT) who developed abnormal glucose regulation (n=240) were pair matched to controls for age and family history of diabetes and also compared to men of the same age (n=355). RESULTS: Low fasting IGFBP1 and increased waist measurement predicted development of diabetes in women (n=60; odds ratio (OR) 70, 95{\%} confidence interval (CI) 8-661, lowest tertile and OR 27, 95{\%} CI 5-141, highest tertile). In women developing diabetes, baseline IGFBP1 levels were lower than expected for fasting insulin values, were associated with impaired suppression after OGTT and increased during 8 years despite an increase in fasting insulin. All individuals in the highest tertile for waist and with <or=40{\%} suppression of IGFBP1 developed diabetes within 8 years. Circulating IGFBP1 concentrations were higher in women compared to men. Women and men who developed diabetes had a similar degree of abdominal obesity, corrected for height. CONCLUSIONS: We conclude that low IGFBP1 and elevated waist measurement predict diabetes development and that IGFBP1 production is suppressed by a novel factor(s) in women developing diabetes. Increasing levels of IGFBP1 during the emergence of diabetes in men and women suggest the emergence of hepatic insulin resistance.",
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IGF-binding protein 1 and abdominal obesity in the development of type 2 diabetes in women. / Lewitt, Moira; Hilding, Agneta; Brismar, Kerstin; Efendic, Suad; Östenson, Claes-Göran; Hall, Kerstin.

In: European Journal of Endocrinology, Vol. 163, No. 2, 2010, p. 233-242.

Research output: Contribution to journalArticle

TY - JOUR

T1 - IGF-binding protein 1 and abdominal obesity in the development of type 2 diabetes in women

AU - Lewitt, Moira

AU - Hilding, Agneta

AU - Brismar, Kerstin

AU - Efendic, Suad

AU - Östenson, Claes-Göran

AU - Hall, Kerstin

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: Low levels of IGF-binding protein 1 (IGFBP1) are associated with metabolic syndrome and predict diabetes development in men. The aim of this study was to determine the levels of IGFBP1 in women who later develop diabetes, in relation to abdominal obesity, and to compare these levels with those of men. METHODS: IGFBP1 levels were determined at baseline and after 8 years in a case-control, prospective study of Swedish women aged 35-56 years. Individuals with normal oral glucose tolerance test (OGTT) who developed abnormal glucose regulation (n=240) were pair matched to controls for age and family history of diabetes and also compared to men of the same age (n=355). RESULTS: Low fasting IGFBP1 and increased waist measurement predicted development of diabetes in women (n=60; odds ratio (OR) 70, 95% confidence interval (CI) 8-661, lowest tertile and OR 27, 95% CI 5-141, highest tertile). In women developing diabetes, baseline IGFBP1 levels were lower than expected for fasting insulin values, were associated with impaired suppression after OGTT and increased during 8 years despite an increase in fasting insulin. All individuals in the highest tertile for waist and with <or=40% suppression of IGFBP1 developed diabetes within 8 years. Circulating IGFBP1 concentrations were higher in women compared to men. Women and men who developed diabetes had a similar degree of abdominal obesity, corrected for height. CONCLUSIONS: We conclude that low IGFBP1 and elevated waist measurement predict diabetes development and that IGFBP1 production is suppressed by a novel factor(s) in women developing diabetes. Increasing levels of IGFBP1 during the emergence of diabetes in men and women suggest the emergence of hepatic insulin resistance.

AB - OBJECTIVE: Low levels of IGF-binding protein 1 (IGFBP1) are associated with metabolic syndrome and predict diabetes development in men. The aim of this study was to determine the levels of IGFBP1 in women who later develop diabetes, in relation to abdominal obesity, and to compare these levels with those of men. METHODS: IGFBP1 levels were determined at baseline and after 8 years in a case-control, prospective study of Swedish women aged 35-56 years. Individuals with normal oral glucose tolerance test (OGTT) who developed abnormal glucose regulation (n=240) were pair matched to controls for age and family history of diabetes and also compared to men of the same age (n=355). RESULTS: Low fasting IGFBP1 and increased waist measurement predicted development of diabetes in women (n=60; odds ratio (OR) 70, 95% confidence interval (CI) 8-661, lowest tertile and OR 27, 95% CI 5-141, highest tertile). In women developing diabetes, baseline IGFBP1 levels were lower than expected for fasting insulin values, were associated with impaired suppression after OGTT and increased during 8 years despite an increase in fasting insulin. All individuals in the highest tertile for waist and with <or=40% suppression of IGFBP1 developed diabetes within 8 years. Circulating IGFBP1 concentrations were higher in women compared to men. Women and men who developed diabetes had a similar degree of abdominal obesity, corrected for height. CONCLUSIONS: We conclude that low IGFBP1 and elevated waist measurement predict diabetes development and that IGFBP1 production is suppressed by a novel factor(s) in women developing diabetes. Increasing levels of IGFBP1 during the emergence of diabetes in men and women suggest the emergence of hepatic insulin resistance.

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KW - Female

KW - Glucose Tolerance Test

KW - Humans

KW - Insulin/blood

KW - Insulin-Like Growth Factor Binding Protein 1/metabolism

KW - Insulin-Like Growth Factor I/metabolism

KW - Middle Aged

KW - Obesity, Abdominal/metabolism

KW - Odds Ratio

KW - Prospective Studies

KW - Radioimmunoassay

KW - Regression Analysis

KW - Sweden

KW - Waist Circumference

U2 - 10.1530/EJE-10-0301

DO - 10.1530/EJE-10-0301

M3 - Article

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EP - 242

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

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ER -