Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

Xiaoling Wang; Jioji Tabudravu; Mostafa Ezzat Rateb; Krystal Joan Annand; Zhiwei Qin; Marcel Jaspars; Zixin Deng; Yi Yu; Hai Deng

doi:10.1039/c3mb70081j

Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

Xiaoling Wang
, Jioji Tabudravu
, Mostafa Ezzat Rateb
, Krystal Joan Annand
, Zhiwei Qin
, Marcel Jaspars
, Zixin Deng
, Yi Yu
, Hai Deng

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2–3, respectively.

Original language	English
Pages (from-to)	1286-1289
Number of pages	4
Journal	Molecular BioSystems
Issue number	6
DOIs	https://doi.org/10.1039/c3mb70081j
Publication status	Published - 2013
Externally published	Yes

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title = "Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus",

abstract = "The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2–3, respectively.",

author = "Xiaoling Wang and Jioji Tabudravu and Rateb, \{Mostafa Ezzat\} and Annand, \{Krystal Joan\} and Zhiwei Qin and Marcel Jaspars and Zixin Deng and Yi Yu and Hai Deng",

year = "2013",

doi = "10.1039/c3mb70081j",

language = "English",

pages = "1286--1289",

journal = "Molecular BioSystems",

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TY - JOUR

T1 - Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

AU - Wang, Xiaoling

AU - Tabudravu, Jioji

AU - Rateb, Mostafa Ezzat

AU - Annand, Krystal Joan

AU - Qin, Zhiwei

AU - Jaspars, Marcel

AU - Deng, Zixin

AU - Yu, Yi

AU - Deng, Hai

PY - 2013

Y1 - 2013

N2 - The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2–3, respectively.

AB - The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2–3, respectively.

U2 - 10.1039/c3mb70081j

DO - 10.1039/c3mb70081j

M3 - Article

SN - 1742-2051

SP - 1286

EP - 1289

JO - Molecular BioSystems

JF - Molecular BioSystems

IS - 6

ER -

Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

Abstract

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