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Balamuthia mandrillaris encephalitis: slow but lethal march towards the brain

  • Ruqaiyyah Siddiqui
  • , Sutherland K. Maciver
  • , Naveed Ahmed Khan*
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Balamuthia mandrillaris causes granulomatous amebic encephalitis. It is puzzling that unlike many blood-borne pathogens that can invade the central nervous system within hours, B. mandrillaris typically takes weeks to months before culminating in encephalitis. Here, we discuss basis of Balamuthia’s slow pathogenesis with an eye for improving early recognition, therapeutic interventions and identifying novel targets for intervention.

Original languageEnglish
Pages (from-to)e116-e117
Number of pages2
JournalPediatric Infectious Disease Journal
Volume45
Issue number4
DOIs
Publication statusPublished - 30 Apr 2026
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Balamuthia
  • central nervous system
  • encephalitis
  • parasite

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