Acanthamoeba, an environmental phagocyte enhancing survival and transmission of human pathogens

Binod Rayamajhee; Mark D.P. Willcox; Fiona L. Henriquez; Constantinos Petsoglou; Dinesh Subedi; Nicole Carnt

doi:10.1016/j.pt.2022.08.007

Acanthamoeba, an environmental phagocyte enhancing survival and transmission of human pathogens

Binod Rayamajhee^*
, Mark D.P. Willcox^*
, Fiona L. Henriquez
, Constantinos Petsoglou
, Dinesh Subedi
, Nicole Carnt

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

28 Citations (Scopus)

141 Downloads (Pure)

Abstract

The opportunistic protist Acanthamoeba, which interacts with other microbes such as bacteria, fungi, and viruses, shows significant similarity in cellular and functional aspects to human macrophages. Intracellular survival of microbes in this microbivorous amoebal host may be a crucial step for initiation of infection in higher eukaryotic cells. Therefore, Acanthamoeba–microbe adaptations are considered an evolutionary model of macrophage–pathogen interactions. This paper reviews Acanthamoeba as an emerging human pathogen and different ecological interactions between Acanthamoeba and microbes that may serve as environmental training grounds and a genetic melting pot for the evolution, persistence, and transmission of potential human pathogens.

Original language	English
Pages (from-to)	975-990
Number of pages	16
Journal	Trends in Parasitology
Volume	38
Issue number	11
Early online date	12 Sept 2022
DOIs	https://doi.org/10.1016/j.pt.2022.08.007
Publication status	Published - 30 Nov 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

evolution
grazing resistance
microbial symbiosis
phagocytosis
predation
virulence factors

Access to Document

10.1016/j.pt.2022.08.007

2022 08 11 Rayamajhee et al Acanthamoeba acceptedAccepted author manuscript, 1.92 MBLicence: CC BY-NC-ND

Cite this

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title = "Acanthamoeba, an environmental phagocyte enhancing survival and transmission of human pathogens",

abstract = "The opportunistic protist Acanthamoeba, which interacts with other microbes such as bacteria, fungi, and viruses, shows significant similarity in cellular and functional aspects to human macrophages. Intracellular survival of microbes in this microbivorous amoebal host may be a crucial step for initiation of infection in higher eukaryotic cells. Therefore, Acanthamoeba–microbe adaptations are considered an evolutionary model of macrophage–pathogen interactions. This paper reviews Acanthamoeba as an emerging human pathogen and different ecological interactions between Acanthamoeba and microbes that may serve as environmental training grounds and a genetic melting pot for the evolution, persistence, and transmission of potential human pathogens.",

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T1 - Acanthamoeba, an environmental phagocyte enhancing survival and transmission of human pathogens

AU - Rayamajhee, Binod

AU - Willcox, Mark D.P.

AU - Henriquez, Fiona L.

AU - Petsoglou, Constantinos

AU - Subedi, Dinesh

AU - Carnt, Nicole

PY - 2022/11/30

Y1 - 2022/11/30

N2 - The opportunistic protist Acanthamoeba, which interacts with other microbes such as bacteria, fungi, and viruses, shows significant similarity in cellular and functional aspects to human macrophages. Intracellular survival of microbes in this microbivorous amoebal host may be a crucial step for initiation of infection in higher eukaryotic cells. Therefore, Acanthamoeba–microbe adaptations are considered an evolutionary model of macrophage–pathogen interactions. This paper reviews Acanthamoeba as an emerging human pathogen and different ecological interactions between Acanthamoeba and microbes that may serve as environmental training grounds and a genetic melting pot for the evolution, persistence, and transmission of potential human pathogens.

AB - The opportunistic protist Acanthamoeba, which interacts with other microbes such as bacteria, fungi, and viruses, shows significant similarity in cellular and functional aspects to human macrophages. Intracellular survival of microbes in this microbivorous amoebal host may be a crucial step for initiation of infection in higher eukaryotic cells. Therefore, Acanthamoeba–microbe adaptations are considered an evolutionary model of macrophage–pathogen interactions. This paper reviews Acanthamoeba as an emerging human pathogen and different ecological interactions between Acanthamoeba and microbes that may serve as environmental training grounds and a genetic melting pot for the evolution, persistence, and transmission of potential human pathogens.

KW - evolution

KW - grazing resistance

KW - microbial symbiosis

KW - phagocytosis

KW - predation

KW - virulence factors

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DO - 10.1016/j.pt.2022.08.007

M3 - Review article

AN - SCOPUS:85138037102

SN - 1471-4922

VL - 38

SP - 975

EP - 990

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 11

ER -

Acanthamoeba, an environmental phagocyte enhancing survival and transmission of human pathogens

Abstract

UN SDGs

Keywords

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