Herbicidins from Streptomyces sp. CB01388 showing anti-Cryptosporidium activity

Jian-Jun Chen; Mostafa E Rateb; Melissa S Love; Zhengren Xu; Dong Yang; Xiangcheng Zhu; Yong Huang; Li-Xing Zhao; Yi Jiang; Yanwen Duan; Case W McNamara; Ben Shen

doi:10.1021/acs.jnatprod.7b00850

Herbicidins from Streptomyces sp. CB01388 showing anti-Cryptosporidium activity

Jian-Jun Chen, Mostafa E Rateb, Melissa S Love, Zhengren Xu, Dong Yang, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Case W McNamara, Ben Shen

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A high-content imaging assay was used to screen the fraction collection of the Natural Product Library at The Scripps Research Institute for inhibitors of Cryptosporidium parvum. A chemical investigation of one strain, Streptomyces sp. CB01388, resulted in the isolation of six herbicidins (1-6), one of which is new (herbicidin L, 1). Five of the six herbicidins (1-3, 5, 6) showed moderate inhibitory activity against C. parvum, with 1 and 6 comparable to the FDA-approved drug nitazoxanide, and 2-6 showed no toxicity to the host HCT-8 cells and human HEK293T and HepG2 cells. These findings highlight the herbicidin scaffold for anti-Cryptosporidium drug development.

Original language	English
Pages (from-to)	791-797
Journal	Journal of Natural Products
Volume	81
Issue number	4
Early online date	22 Feb 2018
DOIs	https://doi.org/10.1021/acs.jnatprod.7b00850
Publication status	E-pub ahead of print - 22 Feb 2018
Externally published	Yes

Keywords

Journal Article

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10.1021/acs.jnatprod.7b00850

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title = "Herbicidins from Streptomyces sp. CB01388 showing anti-Cryptosporidium activity",

abstract = "A high-content imaging assay was used to screen the fraction collection of the Natural Product Library at The Scripps Research Institute for inhibitors of Cryptosporidium parvum. A chemical investigation of one strain, Streptomyces sp. CB01388, resulted in the isolation of six herbicidins (1-6), one of which is new (herbicidin L, 1). Five of the six herbicidins (1-3, 5, 6) showed moderate inhibitory activity against C. parvum, with 1 and 6 comparable to the FDA-approved drug nitazoxanide, and 2-6 showed no toxicity to the host HCT-8 cells and human HEK293T and HepG2 cells. These findings highlight the herbicidin scaffold for anti-Cryptosporidium drug development.",

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year = "2018",

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doi = "10.1021/acs.jnatprod.7b00850",

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T1 - Herbicidins from Streptomyces sp. CB01388 showing anti-Cryptosporidium activity

AU - Chen, Jian-Jun

AU - Rateb, Mostafa E

AU - Love, Melissa S

AU - Xu, Zhengren

AU - Yang, Dong

AU - Zhu, Xiangcheng

AU - Huang, Yong

AU - Zhao, Li-Xing

AU - Jiang, Yi

AU - Duan, Yanwen

AU - McNamara, Case W

AU - Shen, Ben

PY - 2018/2/22

Y1 - 2018/2/22

N2 - A high-content imaging assay was used to screen the fraction collection of the Natural Product Library at The Scripps Research Institute for inhibitors of Cryptosporidium parvum. A chemical investigation of one strain, Streptomyces sp. CB01388, resulted in the isolation of six herbicidins (1-6), one of which is new (herbicidin L, 1). Five of the six herbicidins (1-3, 5, 6) showed moderate inhibitory activity against C. parvum, with 1 and 6 comparable to the FDA-approved drug nitazoxanide, and 2-6 showed no toxicity to the host HCT-8 cells and human HEK293T and HepG2 cells. These findings highlight the herbicidin scaffold for anti-Cryptosporidium drug development.

AB - A high-content imaging assay was used to screen the fraction collection of the Natural Product Library at The Scripps Research Institute for inhibitors of Cryptosporidium parvum. A chemical investigation of one strain, Streptomyces sp. CB01388, resulted in the isolation of six herbicidins (1-6), one of which is new (herbicidin L, 1). Five of the six herbicidins (1-3, 5, 6) showed moderate inhibitory activity against C. parvum, with 1 and 6 comparable to the FDA-approved drug nitazoxanide, and 2-6 showed no toxicity to the host HCT-8 cells and human HEK293T and HepG2 cells. These findings highlight the herbicidin scaffold for anti-Cryptosporidium drug development.

KW - Journal Article

U2 - 10.1021/acs.jnatprod.7b00850

DO - 10.1021/acs.jnatprod.7b00850

M3 - Article

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SN - 0163-3864

VL - 81

SP - 791

EP - 797

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Herbicidins from Streptomyces sp. CB01388 showing anti-Cryptosporidium activity

Abstract

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