Herbicidins from Streptomyces sp. CB01388 showing anti-Cryptosporidium activity

Jian-Jun Chen, Mostafa E Rateb, Melissa S Love, Zhengren Xu, Dong Yang, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Case W McNamara, Ben Shen

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A high-content imaging assay was used to screen the fraction collection of the Natural Product Library at The Scripps Research Institute for inhibitors of Cryptosporidium parvum. A chemical investigation of one strain, Streptomyces sp. CB01388, resulted in the isolation of six herbicidins (1-6), one of which is new (herbicidin L, 1). Five of the six herbicidins (1-3, 5, 6) showed moderate inhibitory activity against C. parvum, with 1 and 6 comparable to the FDA-approved drug nitazoxanide, and 2-6 showed no toxicity to the host HCT-8 cells and human HEK293T and HepG2 cells. These findings highlight the herbicidin scaffold for anti-Cryptosporidium drug development.

Original languageEnglish
Pages (from-to)791-797
JournalJournal of Natural Products
Volume81
Issue number4
Early online date22 Feb 2018
DOIs
Publication statusE-pub ahead of print - 22 Feb 2018
Externally publishedYes

Keywords

  • Journal Article

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