Gold therapy lowers serum interleukin 6 levels in rheumatoid arthritis

R. Madhok, A. Crilly, E. Murphy, J. Smith, John Watson, H.A. Capell

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

OBJECTIVE: To determine the clinical utility and the effect of sodium aurothiomalate (GSTM) on serum interleukin 6 (IL-6) levels in patients with rheumatoid arthritis (RA).

METHODS: Open prospective study of 50 patients with RA treated with GSTM. Serum IL-6 measured by bioassay.

RESULTS: IL-6 showed correlations with Ritchie articular index, duration of morning stiffness and C-reactive protein. GSTM significantly reduced IL-6 levels.

CONCLUSIONS: IL-6 is a potentially useful additional indicator of disease activity in RA and is modulated by GSTM.

Original languageEnglish
Pages (from-to)630-3
Number of pages4
JournalClinical Rheumatology
Volume20
Issue number4
Publication statusPublished - Apr 1993
Externally publishedYes

Keywords

  • Arthritis, Rheumatoid
  • Biological Assay
  • Female
  • Gold Sodium Thiomalate
  • Humans
  • Interleukin-6
  • Male
  • Reference Values

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    Madhok, R., Crilly, A., Murphy, E., Smith, J., Watson, J., & Capell, H. A. (1993). Gold therapy lowers serum interleukin 6 levels in rheumatoid arthritis. Clinical Rheumatology, 20(4), 630-3.