GH improves endothelial function & lipid profile but increases RPP & PIIIP in drug users

M. R. Graham, P. J. Evans, B Davies, Fergal Grace, Julien Baker

Research output: Contribution to conferenceOther

Abstract

Background: In hypertensive subjects without a history of overt cardiovascular disease (CVD), arterial pulse wave velocity (APWV) is a surrogate measure of arterial stiffness, arterial endothelial dysfunction and CVD and independently predicts the occurrence of cardiovascular events (Boutouyrie, et al, 2002). Amino-terminal propeptide of type III procollagen (PIIIP) is increased in plasma and arterial aneurysm tissue compared with healthy arterial tissue (Ihara et al., 2004). Anabolic-androgenic steroid (AAS) drug use combined with strength training independently predisposes to endothelial dysfunction and decreased arterial compliance (Kasikcioglu et al., 2007). Objectives: To establish if recombinant human growth hormone (rhGH) in an AAS group affected endothelial function, rate pressure product, lipid profile and PIIIP, compared with a control group. Methods: Male subjects (n=48) were randomly divided, using a single blind procedure into two groups: (1): control group (C) n=24, mean ± SD, age 32 ± 11 years; height 1.8 ± 0.06 metres; 2): rhGH using group (0.019 mg.kg-1.day-1) (GH) n=24, mean ± SD, age 32 ± 9 years; height 1.8 ± 0.07 metres. Physiological responses, anthropometry, arterial pulse wave velocity (APWV), blood pressure (BP), heart rate (HR), and biochemical indices were investigated. Results: Body mass index, fat-free mass index significantly increased, body fat significantly decreased within GH (all P<0.017). Insulin like growth factor-I and PIIIP significantly increased within GH (P<0.017) and compared with C (P<0.05). Serum sodium significantly increased (P<0.017) and serum homocysteine, and high sensitivity C-reactive protein, significantly decreased within GH (all P<0.017). Arterial pulse wave velocity, significantly decreased within GH (P<0.017) and compared with C (P<0.05). Total cholesterol, triglycerides and low density lipoprotein all significantly decreased within GH (P<0.017). Resting HR and rate pressure product (RPP) significantly increased within GH (P<0.017) and compared with C (P<0.05). Conclusion: The elevation in PIIIP supports previous research in the area (Velloso et al., 2006). RhGH therapy has been shown to improve cardiovascular risk factors in strength training athletes, using AAS (Graham et al, 2007), however the current study suggest that short term use of rhGH although having beneficial effects on endothelial function, lipoprotein profile and specific inflammatory markers of cardiovascular disease in AAS drug users, may controversially also have an adverse effect on the cardiovascular system, as evidenced by the increase in resting RPP and PIIIP and should therefore not be recommended in drug users.
Original languageEnglish
Publication statusPublished - Dec 2010
EventCROSS THEMED MEETING - Durham, United Kingdom
Duration: 15 Dec 201017 Dec 2010

Conference

ConferenceCROSS THEMED MEETING
CountryUnited Kingdom
CityDurham
Period15/12/1017/12/10

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Testosterone Congeners
Collagen Type III
Drug Users
Pulse Wave Analysis
Human Growth Hormone
Lipids
Pressure
Growth Hormone
Cardiovascular Diseases
Resistance Training
Heart Rate
Control Groups
Anthropometry
Vascular Stiffness
Homocysteine
Cardiovascular System
Serum
Insulin-Like Growth Factor I
Athletes
C-Reactive Protein

Cite this

Graham, M. R., Evans, P. J., Davies, B., Grace, F., & Baker, J. (2010). GH improves endothelial function & lipid profile but increases RPP & PIIIP in drug users. CROSS THEMED MEETING, Durham, United Kingdom.
Graham, M. R. ; Evans, P. J. ; Davies, B ; Grace, Fergal ; Baker, Julien. / GH improves endothelial function & lipid profile but increases RPP & PIIIP in drug users. CROSS THEMED MEETING, Durham, United Kingdom.
@conference{01f4fcc67e01462a9744ac6b7382a825,
title = "GH improves endothelial function & lipid profile but increases RPP & PIIIP in drug users",
abstract = "Background: In hypertensive subjects without a history of overt cardiovascular disease (CVD), arterial pulse wave velocity (APWV) is a surrogate measure of arterial stiffness, arterial endothelial dysfunction and CVD and independently predicts the occurrence of cardiovascular events (Boutouyrie, et al, 2002). Amino-terminal propeptide of type III procollagen (PIIIP) is increased in plasma and arterial aneurysm tissue compared with healthy arterial tissue (Ihara et al., 2004). Anabolic-androgenic steroid (AAS) drug use combined with strength training independently predisposes to endothelial dysfunction and decreased arterial compliance (Kasikcioglu et al., 2007). Objectives: To establish if recombinant human growth hormone (rhGH) in an AAS group affected endothelial function, rate pressure product, lipid profile and PIIIP, compared with a control group. Methods: Male subjects (n=48) were randomly divided, using a single blind procedure into two groups: (1): control group (C) n=24, mean ± SD, age 32 ± 11 years; height 1.8 ± 0.06 metres; 2): rhGH using group (0.019 mg.kg-1.day-1) (GH) n=24, mean ± SD, age 32 ± 9 years; height 1.8 ± 0.07 metres. Physiological responses, anthropometry, arterial pulse wave velocity (APWV), blood pressure (BP), heart rate (HR), and biochemical indices were investigated. Results: Body mass index, fat-free mass index significantly increased, body fat significantly decreased within GH (all P<0.017). Insulin like growth factor-I and PIIIP significantly increased within GH (P<0.017) and compared with C (P<0.05). Serum sodium significantly increased (P<0.017) and serum homocysteine, and high sensitivity C-reactive protein, significantly decreased within GH (all P<0.017). Arterial pulse wave velocity, significantly decreased within GH (P<0.017) and compared with C (P<0.05). Total cholesterol, triglycerides and low density lipoprotein all significantly decreased within GH (P<0.017). Resting HR and rate pressure product (RPP) significantly increased within GH (P<0.017) and compared with C (P<0.05). Conclusion: The elevation in PIIIP supports previous research in the area (Velloso et al., 2006). RhGH therapy has been shown to improve cardiovascular risk factors in strength training athletes, using AAS (Graham et al, 2007), however the current study suggest that short term use of rhGH although having beneficial effects on endothelial function, lipoprotein profile and specific inflammatory markers of cardiovascular disease in AAS drug users, may controversially also have an adverse effect on the cardiovascular system, as evidenced by the increase in resting RPP and PIIIP and should therefore not be recommended in drug users.",
author = "Graham, {M. R.} and Evans, {P. J.} and B Davies and Fergal Grace and Julien Baker",
year = "2010",
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}

Graham, MR, Evans, PJ, Davies, B, Grace, F & Baker, J 2010, 'GH improves endothelial function & lipid profile but increases RPP & PIIIP in drug users' CROSS THEMED MEETING, Durham, United Kingdom, 15/12/10 - 17/12/10, .

GH improves endothelial function & lipid profile but increases RPP & PIIIP in drug users. / Graham, M. R.; Evans, P. J.; Davies, B; Grace, Fergal; Baker, Julien.

2010. CROSS THEMED MEETING, Durham, United Kingdom.

Research output: Contribution to conferenceOther

TY - CONF

T1 - GH improves endothelial function & lipid profile but increases RPP & PIIIP in drug users

AU - Graham, M. R.

AU - Evans, P. J.

AU - Davies, B

AU - Grace, Fergal

AU - Baker, Julien

PY - 2010/12

Y1 - 2010/12

N2 - Background: In hypertensive subjects without a history of overt cardiovascular disease (CVD), arterial pulse wave velocity (APWV) is a surrogate measure of arterial stiffness, arterial endothelial dysfunction and CVD and independently predicts the occurrence of cardiovascular events (Boutouyrie, et al, 2002). Amino-terminal propeptide of type III procollagen (PIIIP) is increased in plasma and arterial aneurysm tissue compared with healthy arterial tissue (Ihara et al., 2004). Anabolic-androgenic steroid (AAS) drug use combined with strength training independently predisposes to endothelial dysfunction and decreased arterial compliance (Kasikcioglu et al., 2007). Objectives: To establish if recombinant human growth hormone (rhGH) in an AAS group affected endothelial function, rate pressure product, lipid profile and PIIIP, compared with a control group. Methods: Male subjects (n=48) were randomly divided, using a single blind procedure into two groups: (1): control group (C) n=24, mean ± SD, age 32 ± 11 years; height 1.8 ± 0.06 metres; 2): rhGH using group (0.019 mg.kg-1.day-1) (GH) n=24, mean ± SD, age 32 ± 9 years; height 1.8 ± 0.07 metres. Physiological responses, anthropometry, arterial pulse wave velocity (APWV), blood pressure (BP), heart rate (HR), and biochemical indices were investigated. Results: Body mass index, fat-free mass index significantly increased, body fat significantly decreased within GH (all P<0.017). Insulin like growth factor-I and PIIIP significantly increased within GH (P<0.017) and compared with C (P<0.05). Serum sodium significantly increased (P<0.017) and serum homocysteine, and high sensitivity C-reactive protein, significantly decreased within GH (all P<0.017). Arterial pulse wave velocity, significantly decreased within GH (P<0.017) and compared with C (P<0.05). Total cholesterol, triglycerides and low density lipoprotein all significantly decreased within GH (P<0.017). Resting HR and rate pressure product (RPP) significantly increased within GH (P<0.017) and compared with C (P<0.05). Conclusion: The elevation in PIIIP supports previous research in the area (Velloso et al., 2006). RhGH therapy has been shown to improve cardiovascular risk factors in strength training athletes, using AAS (Graham et al, 2007), however the current study suggest that short term use of rhGH although having beneficial effects on endothelial function, lipoprotein profile and specific inflammatory markers of cardiovascular disease in AAS drug users, may controversially also have an adverse effect on the cardiovascular system, as evidenced by the increase in resting RPP and PIIIP and should therefore not be recommended in drug users.

AB - Background: In hypertensive subjects without a history of overt cardiovascular disease (CVD), arterial pulse wave velocity (APWV) is a surrogate measure of arterial stiffness, arterial endothelial dysfunction and CVD and independently predicts the occurrence of cardiovascular events (Boutouyrie, et al, 2002). Amino-terminal propeptide of type III procollagen (PIIIP) is increased in plasma and arterial aneurysm tissue compared with healthy arterial tissue (Ihara et al., 2004). Anabolic-androgenic steroid (AAS) drug use combined with strength training independently predisposes to endothelial dysfunction and decreased arterial compliance (Kasikcioglu et al., 2007). Objectives: To establish if recombinant human growth hormone (rhGH) in an AAS group affected endothelial function, rate pressure product, lipid profile and PIIIP, compared with a control group. Methods: Male subjects (n=48) were randomly divided, using a single blind procedure into two groups: (1): control group (C) n=24, mean ± SD, age 32 ± 11 years; height 1.8 ± 0.06 metres; 2): rhGH using group (0.019 mg.kg-1.day-1) (GH) n=24, mean ± SD, age 32 ± 9 years; height 1.8 ± 0.07 metres. Physiological responses, anthropometry, arterial pulse wave velocity (APWV), blood pressure (BP), heart rate (HR), and biochemical indices were investigated. Results: Body mass index, fat-free mass index significantly increased, body fat significantly decreased within GH (all P<0.017). Insulin like growth factor-I and PIIIP significantly increased within GH (P<0.017) and compared with C (P<0.05). Serum sodium significantly increased (P<0.017) and serum homocysteine, and high sensitivity C-reactive protein, significantly decreased within GH (all P<0.017). Arterial pulse wave velocity, significantly decreased within GH (P<0.017) and compared with C (P<0.05). Total cholesterol, triglycerides and low density lipoprotein all significantly decreased within GH (P<0.017). Resting HR and rate pressure product (RPP) significantly increased within GH (P<0.017) and compared with C (P<0.05). Conclusion: The elevation in PIIIP supports previous research in the area (Velloso et al., 2006). RhGH therapy has been shown to improve cardiovascular risk factors in strength training athletes, using AAS (Graham et al, 2007), however the current study suggest that short term use of rhGH although having beneficial effects on endothelial function, lipoprotein profile and specific inflammatory markers of cardiovascular disease in AAS drug users, may controversially also have an adverse effect on the cardiovascular system, as evidenced by the increase in resting RPP and PIIIP and should therefore not be recommended in drug users.

M3 - Other

ER -

Graham MR, Evans PJ, Davies B, Grace F, Baker J. GH improves endothelial function & lipid profile but increases RPP & PIIIP in drug users. 2010. CROSS THEMED MEETING, Durham, United Kingdom.