Germicidins H-J from Streptomyces sp. CB00361

Ming Ma, Mostafa Rateb, Dong Yang, Jeffrey D. Rudolf, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Ben Shen

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Abstract

α-Pyrones and natural products featuring an α-pyrone moiety are well known from bacteria, fungi, plants and animals, and they exhibit a wide range of biological activities. The germicidins are a family of microbial α-pyrone natural products, featuring a 4-hydroxy-α-pyrone core with varying alkyl substitutions at C-3 and C-6 (Figure 1). Identified as the first autoregulators of spore germination in Streptomyces, germicidin A (1) and B were first isolated from Streptomyces viridochromogenes NRRL B-1551 and subsequently re-isolated from S. coelicolor.

Original languageEnglish
JournalThe Journal of Antibiotics
Early online date10 Aug 2016
DOIs
Publication statusE-pub ahead of print - 10 Aug 2016
Externally publishedYes

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Ma, M., Rateb, M., Yang, D., Rudolf, J. D., Zhu, X., Huang, Y., ... Shen, B. (2016). Germicidins H-J from Streptomyces sp. CB00361. The Journal of Antibiotics. https://doi.org/10.1038/ja.2016.100