Germicidins H-J from Streptomyces sp. CB00361

Ming Ma; Mostafa Rateb; Dong Yang; Jeffrey D. Rudolf; Xiangcheng Zhu; Yong Huang; Li-Xing Zhao; Yi Jiang; Yanwen Duan; Ben Shen

doi:10.1038/ja.2016.100

Germicidins H-J from Streptomyces sp. CB00361

Ming Ma, Mostafa Rateb, Dong Yang, Jeffrey D. Rudolf, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Ben Shen

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Abstract

α-Pyrones and natural products featuring an α-pyrone moiety are well known from bacteria, fungi, plants and animals, and they exhibit a wide range of biological activities. The germicidins are a family of microbial α-pyrone natural products, featuring a 4-hydroxy-α-pyrone core with varying alkyl substitutions at C-3 and C-6 (Figure 1). Identified as the first autoregulators of spore germination in Streptomyces, germicidin A (1) and B were first isolated from Streptomyces viridochromogenes NRRL B-1551 and subsequently re-isolated from S. coelicolor.

Original language	English
Pages (from-to)	200-203
Number of pages	4
Journal	The Journal of Antibiotics
Volume	70
Issue number	2
Early online date	10 Aug 2016
DOIs	https://doi.org/10.1038/ja.2016.100
Publication status	E-pub ahead of print - 10 Aug 2016
Externally published	Yes

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title = "Germicidins H-J from Streptomyces sp. CB00361",

abstract = "α-Pyrones and natural products featuring an α-pyrone moiety are well known from bacteria, fungi, plants and animals, and they exhibit a wide range of biological activities. The germicidins are a family of microbial α-pyrone natural products, featuring a 4-hydroxy-α-pyrone core with varying alkyl substitutions at C-3 and C-6 (Figure 1). Identified as the first autoregulators of spore germination in Streptomyces, germicidin A (1) and B were first isolated from Streptomyces viridochromogenes NRRL B-1551 and subsequently re-isolated from S. coelicolor.",

author = "Ming Ma and Mostafa Rateb and Dong Yang and Rudolf, {Jeffrey D.} and Xiangcheng Zhu and Yong Huang and Li-Xing Zhao and Yi Jiang and Yanwen Duan and Ben Shen",

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doi = "10.1038/ja.2016.100",

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AU - Ma, Ming

AU - Rateb, Mostafa

AU - Yang, Dong

AU - Rudolf, Jeffrey D.

AU - Zhu, Xiangcheng

AU - Huang, Yong

AU - Zhao, Li-Xing

AU - Jiang, Yi

AU - Duan, Yanwen

AU - Shen, Ben

PY - 2016/8/10

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N2 - α-Pyrones and natural products featuring an α-pyrone moiety are well known from bacteria, fungi, plants and animals, and they exhibit a wide range of biological activities. The germicidins are a family of microbial α-pyrone natural products, featuring a 4-hydroxy-α-pyrone core with varying alkyl substitutions at C-3 and C-6 (Figure 1). Identified as the first autoregulators of spore germination in Streptomyces, germicidin A (1) and B were first isolated from Streptomyces viridochromogenes NRRL B-1551 and subsequently re-isolated from S. coelicolor.

AB - α-Pyrones and natural products featuring an α-pyrone moiety are well known from bacteria, fungi, plants and animals, and they exhibit a wide range of biological activities. The germicidins are a family of microbial α-pyrone natural products, featuring a 4-hydroxy-α-pyrone core with varying alkyl substitutions at C-3 and C-6 (Figure 1). Identified as the first autoregulators of spore germination in Streptomyces, germicidin A (1) and B were first isolated from Streptomyces viridochromogenes NRRL B-1551 and subsequently re-isolated from S. coelicolor.

U2 - 10.1038/ja.2016.100

DO - 10.1038/ja.2016.100

M3 - Article

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EP - 203

JO - The Journal of Antibiotics

JF - The Journal of Antibiotics

IS - 2

ER -

Germicidins H-J from Streptomyces sp. CB00361

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