TY - JOUR
T1 - Gelatin nanofibers
T2 - recent insights in synthesis, bio-medical applications and limitations
AU - El-Seedi, Hesham R.
AU - Said, Noha S.
AU - Yosri, Nermeen
AU - Hawash, Hamada B.
AU - El-Sherif, Dina M.
AU - Abouzid, Mohamed
AU - Abdel-Daim, Mohamed M.
AU - Yaseen, Mohammed
AU - Omar, Hany
AU - Shou, Qiyang
AU - Attia, Nour F.
AU - Zou, Xiaobo
AU - Guo, Zhiming
AU - Khalifa, Shaden A.M.
PY - 2023/5/31
Y1 - 2023/5/31
N2 - The use of gelatin and gelatin-blend polymers as environmentally safe polymers to synthesis electrospun nanofibers, has caused a revolution in the biomedical field. The development of efficient nanofibers has played a significant role in drug delivery, and for use in advanced scaffolds in regenerative medicine. Gelatin is an exceptional biopolymer, which is highly versatile, despite variations in the processing technology. The electrospinning process is an efficient technique for the manufacture of gelatin electrospun nanofibers (GNFs), as it is simple, efficient, and cost-effective. GNFs have higher porosity with large surface area and biocompatibility, despite that there are some drawbacks. These drawbacks include rapid degradation, poor mechanical strength, and complete dissolution, which limits the use of gelatin electrospun nanofibers in this form for biomedicine. Thus, these fibers need to be cross-linked, in order to control its solubility. This modification caused an improvement in the biological properties of GNFs, which made them suitable candidates for various biomedical applications, such as wound healing, drug delivery, bone regeneration, tubular scaffolding, skin, nerve, kidney, and cardiac tissue engineering. In this review an outline of electrospinning is shown with critical summary of literature evaluated with respect to the various applications of nanofibers-derived gelatin.
AB - The use of gelatin and gelatin-blend polymers as environmentally safe polymers to synthesis electrospun nanofibers, has caused a revolution in the biomedical field. The development of efficient nanofibers has played a significant role in drug delivery, and for use in advanced scaffolds in regenerative medicine. Gelatin is an exceptional biopolymer, which is highly versatile, despite variations in the processing technology. The electrospinning process is an efficient technique for the manufacture of gelatin electrospun nanofibers (GNFs), as it is simple, efficient, and cost-effective. GNFs have higher porosity with large surface area and biocompatibility, despite that there are some drawbacks. These drawbacks include rapid degradation, poor mechanical strength, and complete dissolution, which limits the use of gelatin electrospun nanofibers in this form for biomedicine. Thus, these fibers need to be cross-linked, in order to control its solubility. This modification caused an improvement in the biological properties of GNFs, which made them suitable candidates for various biomedical applications, such as wound healing, drug delivery, bone regeneration, tubular scaffolding, skin, nerve, kidney, and cardiac tissue engineering. In this review an outline of electrospinning is shown with critical summary of literature evaluated with respect to the various applications of nanofibers-derived gelatin.
KW - electrospinning
KW - gelatin
KW - medical application
KW - nanofibers
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85159210656&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2023.e16228
DO - 10.1016/j.heliyon.2023.e16228
M3 - Review article
AN - SCOPUS:85159210656
SN - 2405-8440
VL - 9
JO - Heliyon
JF - Heliyon
IS - 5
M1 - e16228
ER -