Abstract

Fungal biofilms are an important clinical problem. A number of factors including the increasing use of indwelling medical devices wider prescription of broad spectrum antibiotics and an aging and more immuno-compromised patient population has combined to create an opportunity for yeasts and moulds to cause infection. It is also becoming increasingly clear that for a number of serious infections the development of a fungal biofilm is important in the pathophysiology of the infection.
This chapter will discuss the importance of fungal biofilms in different anatomical areas, will try to provide insights into how fungal biofilm infection should be diagnosed and treated and provide an explanation as to why biofilms may be difficult to treat effectively with routine antifungal regimens.
Finally it will discuss how our current level of knowledge of the development and biology of fungal biofilms may, in future, lead to a wider choice of therapeutic interventions.
Original languageEnglish
Title of host publicationBiofilm-based Healthcare-associated Infections
EditorsGianfranco Donelli
Place of PublicationCham
PublisherSpringer International Publishing AG
Pages11-27
Number of pages17
ISBN (Electronic)978-3-319-09782-4
ISBN (Print)978-3-319-09781-7
DOIs
Publication statusPublished - 2015

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer International Publishing
Volume831
ISSN (Print)0065-2598

Fingerprint

Biofilms
Infection
Mycoses
Prescriptions
Fungi
Yeasts
Anti-Bacterial Agents
Equipment and Supplies
Population

Cite this

Williams, C., & Ramage, G. (2015). Fungal biofilms in human disease. In G. Donelli (Ed.), Biofilm-based Healthcare-associated Infections (pp. 11-27). (Advances in Experimental Medicine and Biology; Vol. 831). Cham: Springer International Publishing AG. https://doi.org/10.1007/978-3-319-09782-4_2
Williams, Craig ; Ramage, Gordon. / Fungal biofilms in human disease. Biofilm-based Healthcare-associated Infections. editor / Gianfranco Donelli. Cham : Springer International Publishing AG, 2015. pp. 11-27 (Advances in Experimental Medicine and Biology).
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Williams, C & Ramage, G 2015, Fungal biofilms in human disease. in G Donelli (ed.), Biofilm-based Healthcare-associated Infections. Advances in Experimental Medicine and Biology, vol. 831, Springer International Publishing AG, Cham, pp. 11-27. https://doi.org/10.1007/978-3-319-09782-4_2

Fungal biofilms in human disease. / Williams, Craig; Ramage, Gordon.

Biofilm-based Healthcare-associated Infections. ed. / Gianfranco Donelli. Cham : Springer International Publishing AG, 2015. p. 11-27 (Advances in Experimental Medicine and Biology; Vol. 831).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Williams C, Ramage G. Fungal biofilms in human disease. In Donelli G, editor, Biofilm-based Healthcare-associated Infections. Cham: Springer International Publishing AG. 2015. p. 11-27. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-09782-4_2