Fungal biofilms in human disease

Craig Williams, Gordon Ramage

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

Fungal biofilms are an important clinical problem. A number of factors including the increasing use of indwelling medical devices wider prescription of broad spectrum antibiotics and an aging and more immuno-compromised patient population has combined to create an opportunity for yeasts and moulds to cause infection. It is also becoming increasingly clear that for a number of serious infections the development of a fungal biofilm is important in the pathophysiology of the infection.
This chapter will discuss the importance of fungal biofilms in different anatomical areas, will try to provide insights into how fungal biofilm infection should be diagnosed and treated and provide an explanation as to why biofilms may be difficult to treat effectively with routine antifungal regimens.
Finally it will discuss how our current level of knowledge of the development and biology of fungal biofilms may, in future, lead to a wider choice of therapeutic interventions.
Original languageEnglish
Title of host publicationBiofilm-based Healthcare-associated Infections
EditorsGianfranco Donelli
Place of PublicationCham
PublisherSpringer International Publishing AG
Pages11-27
Number of pages17
ISBN (Electronic)978-3-319-09782-4
ISBN (Print)978-3-319-09781-7
DOIs
Publication statusPublished - 2015

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer International Publishing
Volume831
ISSN (Print)0065-2598

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Cite this

Williams, C., & Ramage, G. (2015). Fungal biofilms in human disease. In G. Donelli (Ed.), Biofilm-based Healthcare-associated Infections (pp. 11-27). (Advances in Experimental Medicine and Biology; Vol. 831). Cham: Springer International Publishing AG. https://doi.org/10.1007/978-3-319-09782-4_2