Fungal biofilm resistance

Gordon Ramage, Ranjith Rajendran, Leighann Sherry, Craig Williams

Research output: Contribution to journalArticlepeer-review

317 Citations (Scopus)

Abstract

Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required. This places a large financial burden on health care providers. This paper aims to illustrate the importance of fungal biofilms, particularly Candida albicans, and discusses some of the key fungal biofilm resistance mechanisms that include, extracellular matrix (ECM), efflux pump activity, persisters, cell density, overexpression of drug targets, stress responses, and the general physiology of the cell. The paper demonstrates the multifaceted nature of fungal biofilm resistance, which encompasses some of the newest data and ideas in the field.

Original languageEnglish
Article number528521
JournalInternational Journal of Microbiology
DOIs
Publication statusPublished - 2012
Externally publishedYes

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