Four new phenolics and antiparasitic secondary metabolites from Flacourtia rukam Zoll. & Mortizi

Naglaa I. Afifi, Abeer S. Moawad, Mohamed A. Zaki, Mostafa E. Rateb, Mohammed H. Rashed, Ibrahim G. Saleh, Mona H. Hetta, Rabab M. Mohammed*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Phytochemical investigation of Flacourtia rukam Zoll. & Mortizi (F. rukam) leaves and bark led to the isolation and characterization of seventeen compounds of which four phenolics were not previously described; 2-[(benzoyloxy)methyl]-phenyl-O-β-xylosyl-(1→2)-β-glucopyranoside (1), 2-[(benzoyloxy)methyl]-4-hydroxyphenyl-O-β-xylosyl-(1→2)-β-D-glucopyranoside (2), 2-hydroxy-5-(2-hydroxyphenoxy)phenoxy-β-glucopyranoside (3) and biphenyl-1,1′,2,2′-tetraol (5). Interestingly, the later compound is known as a synthetic but this is the first report for its isolation from nature. Chemical structures were established using extensive analysis of spectroscopic data (1 D and 2 D NMR and HRESIMS). Biphenyl-1,1,2,2′-tetrol (5) exhibited a good activity against Trypanosoma brucei trypomastigotes with IC50= 6.66 ug/mL. Compounds 2, 5, 9, 10, 11 and 12 showed a good in-vitro anti-inflammatory activity using proteinase inhibitory assay. On the contrary, all tested compounds were inactive as antileishmanial or antimalarial.
Original languageEnglish
JournalNatural Product Research
Early online date26 Apr 2021
DOIs
Publication statusE-pub ahead of print - 26 Apr 2021

Keywords

  • Flacourtia rukam Zol. & Mortizi
  • Salicaceae
  • phenolics
  • antitrypanosomal
  • anti-inflammatory

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