Exosomes in intercellular communication and implications for osteoarthritis (OA)

Sabha Asghar, Gary J. Litherland, John C. Lockhart, Carl S. Goodyear, Anne Crilly*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Osteoarthritis (OA) is the most prevalent of the musculoskeletal conditions and represents a significant public health burden. While degeneration of articular cartilage is a key feature, it is now increasingly recognised as a complex condition affecting the whole joint, with synovial inflammation present in a significant proportion of patients. As a secretory tissue, the OA synovium is a rich source of both soluble inflammatory mediators and extracellular vesicles (EV), including exosomes, which have been implicated in cell-cell communication. Exosome cargo has been found to include proteins, lipids and various RNA subtypes such as mRNA and miRNA, potentially capable of regulating gene expression in target cells after fusion with the plasma membrane. Investigation of OA synovial tissue exosome cargo and understanding its effect on cartilage (patho)physiology could elucidate novel regulatory mechanisms within the joint, providing insight for targeted treatment.
Original languageEnglish
Article numberkez462
Number of pages12
JournalRheumatology
DOIs
Publication statusPublished - 18 Oct 2019

Fingerprint

Exosomes
Osteoarthritis
Joints
Synovial Membrane
Cell Fusion
Articular Cartilage
MicroRNAs
Cell Communication
Cartilage
Public Health
Cell Membrane
RNA
Inflammation
Lipids
Gene Expression
Messenger RNA
Proteins
Therapeutics

Keywords

  • Osteoarthritis (OA)
  • Exosomes
  • Inflammation
  • Cartilage
  • Synovium
  • Synovitis
  • Microvesicles
  • mRNA
  • microRNA

Cite this

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title = "Exosomes in intercellular communication and implications for osteoarthritis (OA)",
abstract = "Osteoarthritis (OA) is the most prevalent of the musculoskeletal conditions and represents a significant public health burden. While degeneration of articular cartilage is a key feature, it is now increasingly recognised as a complex condition affecting the whole joint, with synovial inflammation present in a significant proportion of patients. As a secretory tissue, the OA synovium is a rich source of both soluble inflammatory mediators and extracellular vesicles (EV), including exosomes, which have been implicated in cell-cell communication. Exosome cargo has been found to include proteins, lipids and various RNA subtypes such as mRNA and miRNA, potentially capable of regulating gene expression in target cells after fusion with the plasma membrane. Investigation of OA synovial tissue exosome cargo and understanding its effect on cartilage (patho)physiology could elucidate novel regulatory mechanisms within the joint, providing insight for targeted treatment.",
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AU - Asghar, Sabha

AU - Litherland, Gary J.

AU - Lockhart, John C.

AU - Goodyear, Carl S.

AU - Crilly, Anne

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N2 - Osteoarthritis (OA) is the most prevalent of the musculoskeletal conditions and represents a significant public health burden. While degeneration of articular cartilage is a key feature, it is now increasingly recognised as a complex condition affecting the whole joint, with synovial inflammation present in a significant proportion of patients. As a secretory tissue, the OA synovium is a rich source of both soluble inflammatory mediators and extracellular vesicles (EV), including exosomes, which have been implicated in cell-cell communication. Exosome cargo has been found to include proteins, lipids and various RNA subtypes such as mRNA and miRNA, potentially capable of regulating gene expression in target cells after fusion with the plasma membrane. Investigation of OA synovial tissue exosome cargo and understanding its effect on cartilage (patho)physiology could elucidate novel regulatory mechanisms within the joint, providing insight for targeted treatment.

AB - Osteoarthritis (OA) is the most prevalent of the musculoskeletal conditions and represents a significant public health burden. While degeneration of articular cartilage is a key feature, it is now increasingly recognised as a complex condition affecting the whole joint, with synovial inflammation present in a significant proportion of patients. As a secretory tissue, the OA synovium is a rich source of both soluble inflammatory mediators and extracellular vesicles (EV), including exosomes, which have been implicated in cell-cell communication. Exosome cargo has been found to include proteins, lipids and various RNA subtypes such as mRNA and miRNA, potentially capable of regulating gene expression in target cells after fusion with the plasma membrane. Investigation of OA synovial tissue exosome cargo and understanding its effect on cartilage (patho)physiology could elucidate novel regulatory mechanisms within the joint, providing insight for targeted treatment.

KW - Osteoarthritis (OA)

KW - Exosomes

KW - Inflammation

KW - Cartilage

KW - Synovium

KW - Synovitis

KW - Microvesicles

KW - mRNA

KW - microRNA

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DO - 10.1093/rheumatology/kez462

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