Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis

Motahare Mokhtarzade, Robert Motl, Raoof Negaresh, Philipp Zimmer, Mostafa Khodadoost, Julien S. Baker, Darpan Patel, Nastaran Majdinasab, Rouholah Ranjbar

Research output: Contribution to journalArticle

9 Citations (Scopus)
129 Downloads (Pure)

Abstract

Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60–70% peak power. Resting blood concentrations of s100 calcium-binding protein B (s100b) and neuron-specific enolase as BBB permeability markers, neurotrophic factors and cytokines (Interleukin-10 and tumor necrosis factor alpha) were evaluated before and after the intervention. There were significant weight, training, and interaction effects on brain-derived neurotrophic factor and platelet-derived growth factor; however, ciliary neurotrophic factor and nerve growth factor did not demonstrate any effect. Brain-derived neurotrophic factor and platelet-derived growth factor were significantly increased from pre-post in normal weight exercise. Significant weight, training, and interaction effects were found for s100b. In detail, s100b was significantly increased from pre-post in normal weight exercise. In contrast, neuron-specific enolase and cytokines did not demonstrate any effect. Generally, Exercise training may alter markers of BBB permeability and neurotrophic factor status in normal weight persons with multiple sclerosis; however, overweight participants may be more resistant to these effects of exercise.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalNeuropeptides
Volume70
Early online date31 May 2018
DOIs
Publication statusPublished - 31 Aug 2018

Fingerprint

Nerve Growth Factors
Blood-Brain Barrier
Multiple Sclerosis
Permeability
Exercise
Weights and Measures
Phosphopyruvate Hydratase
Platelet-Derived Growth Factor
Brain-Derived Neurotrophic Factor
Cytokines
Ciliary Neurotrophic Factor
Relapsing-Remitting Multiple Sclerosis
Calcium-Binding Proteins
Nerve Growth Factor
Interleukin-10
Tumor Necrosis Factor-alpha
Body Weight
Pathology
Control Groups

Keywords

  • blood-brain barrier
  • neurotrophic factors
  • cytokine
  • exercise
  • Excess weight
  • multiple sclerosis

Cite this

Mokhtarzade, Motahare ; Motl, Robert ; Negaresh, Raoof ; Zimmer, Philipp ; Khodadoost, Mostafa ; Baker, Julien S. ; Patel, Darpan ; Majdinasab, Nastaran ; Ranjbar, Rouholah. / Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis. In: Neuropeptides. 2018 ; Vol. 70. pp. 93-100.
@article{d3e5f7d8c7714e99b0fbfc44e902eeb1,
title = "Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis",
abstract = "Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60–70{\%} peak power. Resting blood concentrations of s100 calcium-binding protein B (s100b) and neuron-specific enolase as BBB permeability markers, neurotrophic factors and cytokines (Interleukin-10 and tumor necrosis factor alpha) were evaluated before and after the intervention. There were significant weight, training, and interaction effects on brain-derived neurotrophic factor and platelet-derived growth factor; however, ciliary neurotrophic factor and nerve growth factor did not demonstrate any effect. Brain-derived neurotrophic factor and platelet-derived growth factor were significantly increased from pre-post in normal weight exercise. Significant weight, training, and interaction effects were found for s100b. In detail, s100b was significantly increased from pre-post in normal weight exercise. In contrast, neuron-specific enolase and cytokines did not demonstrate any effect. Generally, Exercise training may alter markers of BBB permeability and neurotrophic factor status in normal weight persons with multiple sclerosis; however, overweight participants may be more resistant to these effects of exercise.",
keywords = "blood-brain barrier, neurotrophic factors, cytokine, exercise, Excess weight, multiple sclerosis",
author = "Motahare Mokhtarzade and Robert Motl and Raoof Negaresh and Philipp Zimmer and Mostafa Khodadoost and Baker, {Julien S.} and Darpan Patel and Nastaran Majdinasab and Rouholah Ranjbar",
year = "2018",
month = "8",
day = "31",
doi = "10.1016/j.npep.2018.05.010",
language = "English",
volume = "70",
pages = "93--100",
journal = "Neuropeptides",
issn = "0143-4179",
publisher = "Elsevier B.V.",

}

Mokhtarzade, M, Motl, R, Negaresh, R, Zimmer, P, Khodadoost, M, Baker, JS, Patel, D, Majdinasab, N & Ranjbar, R 2018, 'Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis', Neuropeptides, vol. 70, pp. 93-100. https://doi.org/10.1016/j.npep.2018.05.010

Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis. / Mokhtarzade, Motahare; Motl, Robert; Negaresh, Raoof; Zimmer, Philipp; Khodadoost, Mostafa; Baker, Julien S.; Patel, Darpan; Majdinasab, Nastaran; Ranjbar, Rouholah.

In: Neuropeptides, Vol. 70, 31.08.2018, p. 93-100.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis

AU - Mokhtarzade, Motahare

AU - Motl, Robert

AU - Negaresh, Raoof

AU - Zimmer, Philipp

AU - Khodadoost, Mostafa

AU - Baker, Julien S.

AU - Patel, Darpan

AU - Majdinasab, Nastaran

AU - Ranjbar, Rouholah

PY - 2018/8/31

Y1 - 2018/8/31

N2 - Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60–70% peak power. Resting blood concentrations of s100 calcium-binding protein B (s100b) and neuron-specific enolase as BBB permeability markers, neurotrophic factors and cytokines (Interleukin-10 and tumor necrosis factor alpha) were evaluated before and after the intervention. There were significant weight, training, and interaction effects on brain-derived neurotrophic factor and platelet-derived growth factor; however, ciliary neurotrophic factor and nerve growth factor did not demonstrate any effect. Brain-derived neurotrophic factor and platelet-derived growth factor were significantly increased from pre-post in normal weight exercise. Significant weight, training, and interaction effects were found for s100b. In detail, s100b was significantly increased from pre-post in normal weight exercise. In contrast, neuron-specific enolase and cytokines did not demonstrate any effect. Generally, Exercise training may alter markers of BBB permeability and neurotrophic factor status in normal weight persons with multiple sclerosis; however, overweight participants may be more resistant to these effects of exercise.

AB - Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15). The intervention consisted of 8 weeks (3 days per week) of cycling undertaken at 60–70% peak power. Resting blood concentrations of s100 calcium-binding protein B (s100b) and neuron-specific enolase as BBB permeability markers, neurotrophic factors and cytokines (Interleukin-10 and tumor necrosis factor alpha) were evaluated before and after the intervention. There were significant weight, training, and interaction effects on brain-derived neurotrophic factor and platelet-derived growth factor; however, ciliary neurotrophic factor and nerve growth factor did not demonstrate any effect. Brain-derived neurotrophic factor and platelet-derived growth factor were significantly increased from pre-post in normal weight exercise. Significant weight, training, and interaction effects were found for s100b. In detail, s100b was significantly increased from pre-post in normal weight exercise. In contrast, neuron-specific enolase and cytokines did not demonstrate any effect. Generally, Exercise training may alter markers of BBB permeability and neurotrophic factor status in normal weight persons with multiple sclerosis; however, overweight participants may be more resistant to these effects of exercise.

KW - blood-brain barrier

KW - neurotrophic factors

KW - cytokine

KW - exercise

KW - Excess weight

KW - multiple sclerosis

U2 - 10.1016/j.npep.2018.05.010

DO - 10.1016/j.npep.2018.05.010

M3 - Article

VL - 70

SP - 93

EP - 100

JO - Neuropeptides

JF - Neuropeptides

SN - 0143-4179

ER -