Evidence of hyperhomocysteinemia following long-term anabolic androgenic steroid (AAS) use

F.M. Grace, N. Sculthorpe, M. Graham, J.S. Baker, T. Gorvette, D. Hullin, B. Davies

Research output: Contribution to journalMeeting Abstract

Abstract

Aim

The purpose of this study was to examine the effects of long-term (>20 years) administration of anabolic androgenic steroids (AAS) on plasma homocysteine (HCY), Vitamin B12 and Folate concentrations.

Methods

Subjects (n = 40) were divided into four distinct groups: AAS users (n = 10) who were still using at time of testing (SU), a group of AAS users (n = 10) who had been abstinent from AAS administration for a period greater than three months prior to examination (SA), Bodybuilding controls (n = 10) who did not use
any pharmacological ergogenic aids (BC), and (n = 10) sedentary male controls (SC).

Results

HCY was significantly higher in SU compared with BC, SC (P < 0.01), and with SA (P < 0.05). Fat free mass was significantly higher in both groups of AAS users (P < 0.01). Daily Energy Intake and Daily Protein Intake (%) was significantly higher
(P < 0.05) in SU and SA compared with BC and SC groups, but was unlikely to be responsible for the observed HCY elevations. Haematology was unremarkable between groups except that of Haematocrit (HCT) concentrations which were significantly higher (P < 0.01) in the SU group. A significant inverse relationship was observed between sex hormone binding globulin (SHBG) and HCY,
particularly in the SU group (r = -0.828, P < 0.01), indicating a possible influence of the sex hormones in determining HCY levels.

Conclusion

With the surmounting evidence linking the capacity for AAS to adversely affect a number of clotting factors, the significantly higher levels of HCY and HCT observed in the SU group, suggests that long-term AAS users are at an increased risk of developing future thrombo-embolytic events.
Original languageEnglish
Pages (from-to)609-609
Number of pages1
JournalAnnals of Nutrition and Metabolism
Volume47
DOIs
Publication statusPublished - 2003
Externally publishedYes

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Testosterone Congeners
Hyperhomocysteinemia
Homocysteine
Hematocrit
Sex Hormone-Binding Globulin
Blood Coagulation Factors
Gonadal Steroid Hormones
Hematology
Vitamin B 12
Energy Intake
Folic Acid
Fats
Pharmacology
Control Groups

Cite this

Grace, F. M., Sculthorpe, N., Graham, M., Baker, J. S., Gorvette, T., Hullin, D., & Davies, B. (2003). Evidence of hyperhomocysteinemia following long-term anabolic androgenic steroid (AAS) use. Annals of Nutrition and Metabolism, 47, 609-609. https://doi.org/10.1159/000073824
Grace, F.M. ; Sculthorpe, N. ; Graham, M. ; Baker, J.S. ; Gorvette, T. ; Hullin, D. ; Davies, B. / Evidence of hyperhomocysteinemia following long-term anabolic androgenic steroid (AAS) use. In: Annals of Nutrition and Metabolism. 2003 ; Vol. 47. pp. 609-609.
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abstract = "AimThe purpose of this study was to examine the effects of long-term (>20 years) administration of anabolic androgenic steroids (AAS) on plasma homocysteine (HCY), Vitamin B12 and Folate concentrations.MethodsSubjects (n = 40) were divided into four distinct groups: AAS users (n = 10) who were still using at time of testing (SU), a group of AAS users (n = 10) who had been abstinent from AAS administration for a period greater than three months prior to examination (SA), Bodybuilding controls (n = 10) who did not useany pharmacological ergogenic aids (BC), and (n = 10) sedentary male controls (SC).ResultsHCY was significantly higher in SU compared with BC, SC (P < 0.01), and with SA (P < 0.05). Fat free mass was significantly higher in both groups of AAS users (P < 0.01). Daily Energy Intake and Daily Protein Intake ({\%}) was significantly higher(P < 0.05) in SU and SA compared with BC and SC groups, but was unlikely to be responsible for the observed HCY elevations. Haematology was unremarkable between groups except that of Haematocrit (HCT) concentrations which were significantly higher (P < 0.01) in the SU group. A significant inverse relationship was observed between sex hormone binding globulin (SHBG) and HCY,particularly in the SU group (r = -0.828, P < 0.01), indicating a possible influence of the sex hormones in determining HCY levels.ConclusionWith the surmounting evidence linking the capacity for AAS to adversely affect a number of clotting factors, the significantly higher levels of HCY and HCT observed in the SU group, suggests that long-term AAS users are at an increased risk of developing future thrombo-embolytic events.",
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Grace, FM, Sculthorpe, N, Graham, M, Baker, JS, Gorvette, T, Hullin, D & Davies, B 2003, 'Evidence of hyperhomocysteinemia following long-term anabolic androgenic steroid (AAS) use', Annals of Nutrition and Metabolism, vol. 47, pp. 609-609. https://doi.org/10.1159/000073824

Evidence of hyperhomocysteinemia following long-term anabolic androgenic steroid (AAS) use. / Grace, F.M.; Sculthorpe, N.; Graham, M.; Baker, J.S.; Gorvette, T.; Hullin, D.; Davies, B.

In: Annals of Nutrition and Metabolism, Vol. 47, 2003, p. 609-609.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Evidence of hyperhomocysteinemia following long-term anabolic androgenic steroid (AAS) use

AU - Grace, F.M.

AU - Sculthorpe, N.

AU - Graham, M.

AU - Baker, J.S.

AU - Gorvette, T.

AU - Hullin, D.

AU - Davies, B.

PY - 2003

Y1 - 2003

N2 - AimThe purpose of this study was to examine the effects of long-term (>20 years) administration of anabolic androgenic steroids (AAS) on plasma homocysteine (HCY), Vitamin B12 and Folate concentrations.MethodsSubjects (n = 40) were divided into four distinct groups: AAS users (n = 10) who were still using at time of testing (SU), a group of AAS users (n = 10) who had been abstinent from AAS administration for a period greater than three months prior to examination (SA), Bodybuilding controls (n = 10) who did not useany pharmacological ergogenic aids (BC), and (n = 10) sedentary male controls (SC).ResultsHCY was significantly higher in SU compared with BC, SC (P < 0.01), and with SA (P < 0.05). Fat free mass was significantly higher in both groups of AAS users (P < 0.01). Daily Energy Intake and Daily Protein Intake (%) was significantly higher(P < 0.05) in SU and SA compared with BC and SC groups, but was unlikely to be responsible for the observed HCY elevations. Haematology was unremarkable between groups except that of Haematocrit (HCT) concentrations which were significantly higher (P < 0.01) in the SU group. A significant inverse relationship was observed between sex hormone binding globulin (SHBG) and HCY,particularly in the SU group (r = -0.828, P < 0.01), indicating a possible influence of the sex hormones in determining HCY levels.ConclusionWith the surmounting evidence linking the capacity for AAS to adversely affect a number of clotting factors, the significantly higher levels of HCY and HCT observed in the SU group, suggests that long-term AAS users are at an increased risk of developing future thrombo-embolytic events.

AB - AimThe purpose of this study was to examine the effects of long-term (>20 years) administration of anabolic androgenic steroids (AAS) on plasma homocysteine (HCY), Vitamin B12 and Folate concentrations.MethodsSubjects (n = 40) were divided into four distinct groups: AAS users (n = 10) who were still using at time of testing (SU), a group of AAS users (n = 10) who had been abstinent from AAS administration for a period greater than three months prior to examination (SA), Bodybuilding controls (n = 10) who did not useany pharmacological ergogenic aids (BC), and (n = 10) sedentary male controls (SC).ResultsHCY was significantly higher in SU compared with BC, SC (P < 0.01), and with SA (P < 0.05). Fat free mass was significantly higher in both groups of AAS users (P < 0.01). Daily Energy Intake and Daily Protein Intake (%) was significantly higher(P < 0.05) in SU and SA compared with BC and SC groups, but was unlikely to be responsible for the observed HCY elevations. Haematology was unremarkable between groups except that of Haematocrit (HCT) concentrations which were significantly higher (P < 0.01) in the SU group. A significant inverse relationship was observed between sex hormone binding globulin (SHBG) and HCY,particularly in the SU group (r = -0.828, P < 0.01), indicating a possible influence of the sex hormones in determining HCY levels.ConclusionWith the surmounting evidence linking the capacity for AAS to adversely affect a number of clotting factors, the significantly higher levels of HCY and HCT observed in the SU group, suggests that long-term AAS users are at an increased risk of developing future thrombo-embolytic events.

U2 - 10.1159/000073824

DO - 10.1159/000073824

M3 - Meeting Abstract

VL - 47

SP - 609

EP - 609

JO - Annals of Nutrition and Metabolism

JF - Annals of Nutrition and Metabolism

SN - 0250-6807

ER -