Evidence of hyperhomocysteinaemia following long term anabolic androgenic steroid (AAS) use

F.M. Grace, N. Sculthorpe, M.T. Graham, J.S. Baker, T. Garvette, D. Hullin, B. Davies

Research output: Contribution to journalMeeting Abstract

Abstract

Aim
To examine the effects of long term (>20 years) administration of anabolic androgenic steroids (AAS) on plasma homocysteine (HCY), vitamin B12, and folate concentrations.

Methods
Subjects (n = 40) were divided into four distinct groups: AAS users (n = 10) who were still using at time of testing (SU), a group of AAS users (n = 10) who had been abstinent from AAS administration
for more than three months before examination (SA), bodybuilding controls (n = 10) who did not use any pharmacological ergogenic aids (BC), and sedentary male controls (SC) (n = 10).

Results
HCY was significantly higher in SU compared with BC, SC (p<0.01), and SA (p<0.05). Fat free mass was significantly higher in both groups of AAS users (p<0.01). Daily energy intake and daily protein intake (%) were significantly higher (p<0.05) in SU and SA
compared with BC and SC groups, but was unlikely to be responsible for the observed HCY increases. Haematology was unremarkable between the groups except for the packed cell volume which was significantly higher (p<0.01) in the SU group. A significant inverse relation was observed between sex hormone binding globulin and HCY, particularly in the SU group (r = −0.828; p<0.01), indicating a possible
influence of the sex hormones in determining HCY levels.

Conclusion
With the mounting evidence linking the capacity for
AAS to adversely affect a number of clotting factors, the significantly higher levels of HCY and packed cell volume observed in the SU group suggests that long term AAS users are at increased risk of developing future thromboembolytic events.
Original languageEnglish
Pages (from-to)388-389
Number of pages2
JournalBritish Journal of Sports Medicine
Volume36
Issue number5
DOIs
Publication statusPublished - Oct 2002
Externally publishedYes

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Testosterone Congeners
Hyperhomocysteinemia
Homocysteine
Cell Size
Sex Hormone-Binding Globulin
Blood Coagulation Factors
Gonadal Steroid Hormones
Hematology
Vitamin B 12
Energy Intake
Folic Acid
Fats
Pharmacology
Control Groups

Cite this

Grace, F.M. ; Sculthorpe, N. ; Graham, M.T. ; Baker, J.S. ; Garvette, T. ; Hullin, D. ; Davies, B. / Evidence of hyperhomocysteinaemia following long term anabolic androgenic steroid (AAS) use. In: British Journal of Sports Medicine. 2002 ; Vol. 36, No. 5. pp. 388-389.
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title = "Evidence of hyperhomocysteinaemia following long term anabolic androgenic steroid (AAS) use",
abstract = "AimTo examine the effects of long term (>20 years) administration of anabolic androgenic steroids (AAS) on plasma homocysteine (HCY), vitamin B12, and folate concentrations.MethodsSubjects (n = 40) were divided into four distinct groups: AAS users (n = 10) who were still using at time of testing (SU), a group of AAS users (n = 10) who had been abstinent from AAS administrationfor more than three months before examination (SA), bodybuilding controls (n = 10) who did not use any pharmacological ergogenic aids (BC), and sedentary male controls (SC) (n = 10).ResultsHCY was significantly higher in SU compared with BC, SC (p<0.01), and SA (p<0.05). Fat free mass was significantly higher in both groups of AAS users (p<0.01). Daily energy intake and daily protein intake ({\%}) were significantly higher (p<0.05) in SU and SAcompared with BC and SC groups, but was unlikely to be responsible for the observed HCY increases. Haematology was unremarkable between the groups except for the packed cell volume which was significantly higher (p<0.01) in the SU group. A significant inverse relation was observed between sex hormone binding globulin and HCY, particularly in the SU group (r = −0.828; p<0.01), indicating a possibleinfluence of the sex hormones in determining HCY levels.ConclusionWith the mounting evidence linking the capacity forAAS to adversely affect a number of clotting factors, the significantly higher levels of HCY and packed cell volume observed in the SU group suggests that long term AAS users are at increased risk of developing future thromboembolytic events.",
author = "F.M. Grace and N. Sculthorpe and M.T. Graham and J.S. Baker and T. Garvette and D. Hullin and B. Davies",
year = "2002",
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doi = "10.1136/bjsm.36.5.385",
language = "English",
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pages = "388--389",
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Evidence of hyperhomocysteinaemia following long term anabolic androgenic steroid (AAS) use. / Grace, F.M.; Sculthorpe, N.; Graham, M.T.; Baker, J.S.; Garvette, T.; Hullin, D.; Davies, B.

In: British Journal of Sports Medicine, Vol. 36, No. 5, 10.2002, p. 388-389.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Evidence of hyperhomocysteinaemia following long term anabolic androgenic steroid (AAS) use

AU - Grace, F.M.

AU - Sculthorpe, N.

AU - Graham, M.T.

AU - Baker, J.S.

AU - Garvette, T.

AU - Hullin, D.

AU - Davies, B.

PY - 2002/10

Y1 - 2002/10

N2 - AimTo examine the effects of long term (>20 years) administration of anabolic androgenic steroids (AAS) on plasma homocysteine (HCY), vitamin B12, and folate concentrations.MethodsSubjects (n = 40) were divided into four distinct groups: AAS users (n = 10) who were still using at time of testing (SU), a group of AAS users (n = 10) who had been abstinent from AAS administrationfor more than three months before examination (SA), bodybuilding controls (n = 10) who did not use any pharmacological ergogenic aids (BC), and sedentary male controls (SC) (n = 10).ResultsHCY was significantly higher in SU compared with BC, SC (p<0.01), and SA (p<0.05). Fat free mass was significantly higher in both groups of AAS users (p<0.01). Daily energy intake and daily protein intake (%) were significantly higher (p<0.05) in SU and SAcompared with BC and SC groups, but was unlikely to be responsible for the observed HCY increases. Haematology was unremarkable between the groups except for the packed cell volume which was significantly higher (p<0.01) in the SU group. A significant inverse relation was observed between sex hormone binding globulin and HCY, particularly in the SU group (r = −0.828; p<0.01), indicating a possibleinfluence of the sex hormones in determining HCY levels.ConclusionWith the mounting evidence linking the capacity forAAS to adversely affect a number of clotting factors, the significantly higher levels of HCY and packed cell volume observed in the SU group suggests that long term AAS users are at increased risk of developing future thromboembolytic events.

AB - AimTo examine the effects of long term (>20 years) administration of anabolic androgenic steroids (AAS) on plasma homocysteine (HCY), vitamin B12, and folate concentrations.MethodsSubjects (n = 40) were divided into four distinct groups: AAS users (n = 10) who were still using at time of testing (SU), a group of AAS users (n = 10) who had been abstinent from AAS administrationfor more than three months before examination (SA), bodybuilding controls (n = 10) who did not use any pharmacological ergogenic aids (BC), and sedentary male controls (SC) (n = 10).ResultsHCY was significantly higher in SU compared with BC, SC (p<0.01), and SA (p<0.05). Fat free mass was significantly higher in both groups of AAS users (p<0.01). Daily energy intake and daily protein intake (%) were significantly higher (p<0.05) in SU and SAcompared with BC and SC groups, but was unlikely to be responsible for the observed HCY increases. Haematology was unremarkable between the groups except for the packed cell volume which was significantly higher (p<0.01) in the SU group. A significant inverse relation was observed between sex hormone binding globulin and HCY, particularly in the SU group (r = −0.828; p<0.01), indicating a possibleinfluence of the sex hormones in determining HCY levels.ConclusionWith the mounting evidence linking the capacity forAAS to adversely affect a number of clotting factors, the significantly higher levels of HCY and packed cell volume observed in the SU group suggests that long term AAS users are at increased risk of developing future thromboembolytic events.

U2 - 10.1136/bjsm.36.5.385

DO - 10.1136/bjsm.36.5.385

M3 - Meeting Abstract

VL - 36

SP - 388

EP - 389

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

SN - 0306-3674

IS - 5

ER -