Single DNA-nanoparticle binding is used to couple the plasmonic fields of nanophotonic bowtie dimers. The binding event is engineered to tune the resonance peak of the bowtie to correspond with a 633 nm laser. Surface enhanced Raman spectroscopy is performed on an individual bowtie, showing that a single DNA-nanoparticle binding event can be recorded.
Clark, A. W., Thompson, D. G., Graham, D., & Cooper, J. M. (2014). Engineering DNA binding sites to assemble and tune plasmonic nanostructures. Advanced Materials, 26(25), 4286-4292. https://doi.org/10.1002/adma.201400510