Effects of inulin propionate ester incorporated into palatable food products on appetite and resting energy expenditure: a randomised crossover study

Claire S. Byrne, Edward S. Chambers, Tom Preston, Catriona Tedford, Jerusa Brignardello, Isabel Garcia-Perez, Elaine Holmes, Gareth A. Wallis, Douglas J. Morrison, Gary S. Frost

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Abstract

Supplementation with inulin-propionate ester (IPE), which delivers propionate to the colon, suppresses ad libitum energy intake and stimulates the release of satiety hormones acutely in humans, and prevents weight gain. In order to determine whether IPE remains effective when incorporated into food products (FP), IPE needs to be added to a widely accepted food system. A bread roll and fruit smoothie were produced. Twenty-one healthy overweight and obese humans participated. Participants attended an acclimatisation visit and a control visit where they consumed un-supplemented food products (FP). Participants then consumed supplemented-FP, containing 10 g/d inulin or IPE for six days followed by a post-supplementation visit in a randomised crossover design. On study visits, supplemented-FP were consumed for the seventh time and ad libitum energy intake was assessed 420 min later. Blood samples were collected to assess hormones and metabolites. Resting energy expenditure (REE) was measured using indirect calorimetry. Taste and appearance ratings were similar between FP. Ad libitum energy intake was significantly different between treatments, due to a decreased intake following IPE-FP. These observations were not related to changes in blood hormones and metabolites. There was an increase in REE following IPE-FP. However, this effect was lost after correcting for changes in fat free mass. Our results suggest that IPE suppresses appetite and may alter REE following its incorporation into palatable food products.
Original languageEnglish
Article number861
JournalNutrients
Volume11
Issue number4
DOIs
Publication statusPublished - 16 Apr 2019

Fingerprint

resting energy expenditure
Inulin
Propionates
inulin
Appetite
appetite
propionates
Cross-Over Studies
Energy Metabolism
Esters
foods
esters
Food
Fortified Food
Energy Intake
energy intake
hormones
Hormones
metabolites
Indirect Calorimetry

Keywords

  • SCFA
  • Appetite
  • Propionate
  • Energy intake
  • Energy expenditure

Cite this

Byrne, Claire S. ; Chambers, Edward S. ; Preston, Tom ; Tedford, Catriona ; Brignardello, Jerusa ; Garcia-Perez, Isabel ; Holmes, Elaine ; Wallis, Gareth A. ; Morrison, Douglas J. ; Frost, Gary S. / Effects of inulin propionate ester incorporated into palatable food products on appetite and resting energy expenditure : a randomised crossover study. In: Nutrients. 2019 ; Vol. 11, No. 4.
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Byrne, CS, Chambers, ES, Preston, T, Tedford, C, Brignardello, J, Garcia-Perez, I, Holmes, E, Wallis, GA, Morrison, DJ & Frost, GS 2019, 'Effects of inulin propionate ester incorporated into palatable food products on appetite and resting energy expenditure: a randomised crossover study', Nutrients, vol. 11, no. 4, 861. https://doi.org/10.3390/nu11040861

Effects of inulin propionate ester incorporated into palatable food products on appetite and resting energy expenditure : a randomised crossover study. / Byrne, Claire S.; Chambers, Edward S.; Preston, Tom; Tedford, Catriona; Brignardello, Jerusa; Garcia-Perez, Isabel; Holmes, Elaine; Wallis, Gareth A.; Morrison, Douglas J.; Frost, Gary S.

In: Nutrients, Vol. 11, No. 4, 861, 16.04.2019.

Research output: Contribution to journalArticle

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T1 - Effects of inulin propionate ester incorporated into palatable food products on appetite and resting energy expenditure

T2 - a randomised crossover study

AU - Byrne, Claire S.

AU - Chambers, Edward S.

AU - Preston, Tom

AU - Tedford, Catriona

AU - Brignardello, Jerusa

AU - Garcia-Perez, Isabel

AU - Holmes, Elaine

AU - Wallis, Gareth A.

AU - Morrison, Douglas J.

AU - Frost, Gary S.

PY - 2019/4/16

Y1 - 2019/4/16

N2 - Supplementation with inulin-propionate ester (IPE), which delivers propionate to the colon, suppresses ad libitum energy intake and stimulates the release of satiety hormones acutely in humans, and prevents weight gain. In order to determine whether IPE remains effective when incorporated into food products (FP), IPE needs to be added to a widely accepted food system. A bread roll and fruit smoothie were produced. Twenty-one healthy overweight and obese humans participated. Participants attended an acclimatisation visit and a control visit where they consumed un-supplemented food products (FP). Participants then consumed supplemented-FP, containing 10 g/d inulin or IPE for six days followed by a post-supplementation visit in a randomised crossover design. On study visits, supplemented-FP were consumed for the seventh time and ad libitum energy intake was assessed 420 min later. Blood samples were collected to assess hormones and metabolites. Resting energy expenditure (REE) was measured using indirect calorimetry. Taste and appearance ratings were similar between FP. Ad libitum energy intake was significantly different between treatments, due to a decreased intake following IPE-FP. These observations were not related to changes in blood hormones and metabolites. There was an increase in REE following IPE-FP. However, this effect was lost after correcting for changes in fat free mass. Our results suggest that IPE suppresses appetite and may alter REE following its incorporation into palatable food products.

AB - Supplementation with inulin-propionate ester (IPE), which delivers propionate to the colon, suppresses ad libitum energy intake and stimulates the release of satiety hormones acutely in humans, and prevents weight gain. In order to determine whether IPE remains effective when incorporated into food products (FP), IPE needs to be added to a widely accepted food system. A bread roll and fruit smoothie were produced. Twenty-one healthy overweight and obese humans participated. Participants attended an acclimatisation visit and a control visit where they consumed un-supplemented food products (FP). Participants then consumed supplemented-FP, containing 10 g/d inulin or IPE for six days followed by a post-supplementation visit in a randomised crossover design. On study visits, supplemented-FP were consumed for the seventh time and ad libitum energy intake was assessed 420 min later. Blood samples were collected to assess hormones and metabolites. Resting energy expenditure (REE) was measured using indirect calorimetry. Taste and appearance ratings were similar between FP. Ad libitum energy intake was significantly different between treatments, due to a decreased intake following IPE-FP. These observations were not related to changes in blood hormones and metabolites. There was an increase in REE following IPE-FP. However, this effect was lost after correcting for changes in fat free mass. Our results suggest that IPE suppresses appetite and may alter REE following its incorporation into palatable food products.

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KW - Appetite

KW - Propionate

KW - Energy intake

KW - Energy expenditure

U2 - 10.3390/nu11040861

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VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

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ER -