Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status

a systematic review of intervention studies

R. Negaresh, R.W. Motl, P. Zimmer, M. Mokhtarzade, J.S. Baker

Research output: Contribution to journalReview article

Abstract

Background
Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS) that can be tracked through biomarkers of disease status. We investigated the effects of exercise on MS biomarkers associated with CNS status including imaging, blood‐brain barrier (BBB) function and neurotrophic factors.

Methods
We conducted open‐dated searches of Scopus, Medline, EMBASE and the Cochrane Library. We included studies written in English describing interventions of exercise that measured one or more of the biomarkers associated with MS published up to October 2018.

Results
We located a total of 3012 citations through searches in electronic databases. Of these, 16 studies were eligible for review; six studies focused on magnetic resonance imaging (MRI) markers, nine studies focused on neurotrophic factors, and three studies focused on BBB function markers. It is of note that two studies included both neurotrophic factor and BBB function markers and are therefore included across categories of biomarkers in this review. The existing evidence from MRI studies confirmed that exercise training can improve CNS integrity and function. There is evidence of a positive effect of exercise training on modulation of BBB permeability markers and brain‐derived neurotrophic factor.

Conclusions
Exercise successfully improves MRI outcomes and peripheral biomarkers (i.e., brain‐derived neurotrophic factor) in people with multiple sclerosis. This suggests that exercise can be recommended as an adjuvant therapy for MS treatment. This conclusion is tempered by some methodological limitations including small sample sizes and high drop‐out rates in the reviewed studies.
Original languageEnglish
Pages (from-to)711-721
Number of pages11
JournalEuropean Journal of Neurology
Volume26
Issue number5
Early online date8 Feb 2019
DOIs
Publication statusPublished - 31 May 2019

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Central Nervous System Diseases
Nerve Growth Factors
Multiple Sclerosis
Biomarkers
Exercise
Central Nervous System
Magnetic Resonance Imaging
Demyelinating Diseases
Sclerosis
Neurodegenerative Diseases
Sample Size
Libraries
Permeability
Databases

Keywords

  • biomarkers
  • blood-brain barriers
  • magnetic resonance imaging
  • multiple sclerosis
  • neurotrophic factor

Cite this

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title = "Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status: a systematic review of intervention studies",
abstract = "BackgroundMultiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS) that can be tracked through biomarkers of disease status. We investigated the effects of exercise on MS biomarkers associated with CNS status including imaging, blood‐brain barrier (BBB) function and neurotrophic factors.MethodsWe conducted open‐dated searches of Scopus, Medline, EMBASE and the Cochrane Library. We included studies written in English describing interventions of exercise that measured one or more of the biomarkers associated with MS published up to October 2018.ResultsWe located a total of 3012 citations through searches in electronic databases. Of these, 16 studies were eligible for review; six studies focused on magnetic resonance imaging (MRI) markers, nine studies focused on neurotrophic factors, and three studies focused on BBB function markers. It is of note that two studies included both neurotrophic factor and BBB function markers and are therefore included across categories of biomarkers in this review. The existing evidence from MRI studies confirmed that exercise training can improve CNS integrity and function. There is evidence of a positive effect of exercise training on modulation of BBB permeability markers and brain‐derived neurotrophic factor.ConclusionsExercise successfully improves MRI outcomes and peripheral biomarkers (i.e., brain‐derived neurotrophic factor) in people with multiple sclerosis. This suggests that exercise can be recommended as an adjuvant therapy for MS treatment. This conclusion is tempered by some methodological limitations including small sample sizes and high drop‐out rates in the reviewed studies.",
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Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status : a systematic review of intervention studies. / Negaresh, R.; Motl, R.W.; Zimmer, P.; Mokhtarzade, M.; Baker, J.S.

In: European Journal of Neurology, Vol. 26, No. 5, 31.05.2019, p. 711-721.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status

T2 - a systematic review of intervention studies

AU - Negaresh, R.

AU - Motl, R.W.

AU - Zimmer, P.

AU - Mokhtarzade, M.

AU - Baker, J.S.

PY - 2019/5/31

Y1 - 2019/5/31

N2 - BackgroundMultiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS) that can be tracked through biomarkers of disease status. We investigated the effects of exercise on MS biomarkers associated with CNS status including imaging, blood‐brain barrier (BBB) function and neurotrophic factors.MethodsWe conducted open‐dated searches of Scopus, Medline, EMBASE and the Cochrane Library. We included studies written in English describing interventions of exercise that measured one or more of the biomarkers associated with MS published up to October 2018.ResultsWe located a total of 3012 citations through searches in electronic databases. Of these, 16 studies were eligible for review; six studies focused on magnetic resonance imaging (MRI) markers, nine studies focused on neurotrophic factors, and three studies focused on BBB function markers. It is of note that two studies included both neurotrophic factor and BBB function markers and are therefore included across categories of biomarkers in this review. The existing evidence from MRI studies confirmed that exercise training can improve CNS integrity and function. There is evidence of a positive effect of exercise training on modulation of BBB permeability markers and brain‐derived neurotrophic factor.ConclusionsExercise successfully improves MRI outcomes and peripheral biomarkers (i.e., brain‐derived neurotrophic factor) in people with multiple sclerosis. This suggests that exercise can be recommended as an adjuvant therapy for MS treatment. This conclusion is tempered by some methodological limitations including small sample sizes and high drop‐out rates in the reviewed studies.

AB - BackgroundMultiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS) that can be tracked through biomarkers of disease status. We investigated the effects of exercise on MS biomarkers associated with CNS status including imaging, blood‐brain barrier (BBB) function and neurotrophic factors.MethodsWe conducted open‐dated searches of Scopus, Medline, EMBASE and the Cochrane Library. We included studies written in English describing interventions of exercise that measured one or more of the biomarkers associated with MS published up to October 2018.ResultsWe located a total of 3012 citations through searches in electronic databases. Of these, 16 studies were eligible for review; six studies focused on magnetic resonance imaging (MRI) markers, nine studies focused on neurotrophic factors, and three studies focused on BBB function markers. It is of note that two studies included both neurotrophic factor and BBB function markers and are therefore included across categories of biomarkers in this review. The existing evidence from MRI studies confirmed that exercise training can improve CNS integrity and function. There is evidence of a positive effect of exercise training on modulation of BBB permeability markers and brain‐derived neurotrophic factor.ConclusionsExercise successfully improves MRI outcomes and peripheral biomarkers (i.e., brain‐derived neurotrophic factor) in people with multiple sclerosis. This suggests that exercise can be recommended as an adjuvant therapy for MS treatment. This conclusion is tempered by some methodological limitations including small sample sizes and high drop‐out rates in the reviewed studies.

KW - biomarkers

KW - blood-brain barriers

KW - magnetic resonance imaging

KW - multiple sclerosis

KW - neurotrophic factor

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M3 - Review article

VL - 26

SP - 711

EP - 721

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

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ER -