Effects of exercise training on cytokines and adipokines in multiple sclerosis: a systematic review

Raoof Negaresh, Robert W. Motl, Motahare Mokhtarzade, Ulrik Dalgas, Darpan Patel, Mehdieh Molanouri Shamsi, Nastaran Majdinasab, Rouholah Ranjbar, Philipp Zimmer, Julien Baker

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Abstract

Background: Physical activity, particularly exercise training, is an evidence-based approach for managing symptoms, restoring function and improving overall wellness in people with multiple sclerosis (MS). Several recent studies have argued for a potential disease modifying effect of exercise in people with MS, and among the potential mediating mechanisms are exercise training effects on both cytokines and adipokines. The objectives of this study were to perform a systematic review of exercise training effects on cytokine and adipokine profiles in persons with MS.

Methods: We conducted open-dated searches of PubMed, Cochrane Library, EMBASE and PEDro using the terms ‘Multiple sclerosis’ or ‘MS’ AND ‘exercise’ OR ‘training’ OR ‘physical activity’ AND ‘cytokine’ OR ‘inflammatory’ OR ‘immune’ OR ‘adipokine’. Included studies were written in English; comprised of humans with MS, and evaluated the effects of regular physical activity or exercise on pro-inflammatory, anti-inflammatory cytokines or adipokines. Two authors independently scanned titles and abstracts, and read the studies included. All studies were rated on the PEDro scale and further classified based on American Academy of Neurology criteria.

Results: Twelve studies were included of which 10 studies focused on cytokines, 1 study focused on adipokines, and 1 study included both cytokines and adipokines. The selected studies included 3 Class I studies, 7 Class II studies, and 2 Class IV studies and had average PEDro scores of 6.9±1.6. Studies included endurance (n=5), resistance (n=3), combined (n=3), and vibration (n=1) training. Overall, there is a general lack of standardization of procedures across studies and inconsistent evidence for the effects of physical activity and exercise on cytokine and adipokine profiles in MS, with a general pattern indicating a lack of effect.

Conclusion: Research regarding the effects of exercise training on cytokines and adipokines in MS is in its infancy, but exercise represents an adjuvant therapy in MS, and future studies are essential for clarifying the role of exercise on cytokines and adipokines in MS.
Original languageEnglish
Pages (from-to)91-100
JournalMultiple Sclerosis and Related Disorders
Volume24
Early online date27 Jun 2018
DOIs
Publication statusPublished - 1 Aug 2018

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Adipokines
Multiple Sclerosis
Exercise
Cytokines
Vibration
PubMed
Libraries
Teaching
Anti-Inflammatory Agents

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Negaresh, Raoof ; Motl, Robert W. ; Mokhtarzade, Motahare ; Dalgas, Ulrik ; Patel, Darpan ; Shamsi, Mehdieh Molanouri ; Majdinasab, Nastaran ; Ranjbar, Rouholah ; Zimmer, Philipp ; Baker, Julien. / Effects of exercise training on cytokines and adipokines in multiple sclerosis : a systematic review. In: Multiple Sclerosis and Related Disorders . 2018 ; Vol. 24. pp. 91-100.
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abstract = "Background: Physical activity, particularly exercise training, is an evidence-based approach for managing symptoms, restoring function and improving overall wellness in people with multiple sclerosis (MS). Several recent studies have argued for a potential disease modifying effect of exercise in people with MS, and among the potential mediating mechanisms are exercise training effects on both cytokines and adipokines. The objectives of this study were to perform a systematic review of exercise training effects on cytokine and adipokine profiles in persons with MS. Methods: We conducted open-dated searches of PubMed, Cochrane Library, EMBASE and PEDro using the terms ‘Multiple sclerosis’ or ‘MS’ AND ‘exercise’ OR ‘training’ OR ‘physical activity’ AND ‘cytokine’ OR ‘inflammatory’ OR ‘immune’ OR ‘adipokine’. Included studies were written in English; comprised of humans with MS, and evaluated the effects of regular physical activity or exercise on pro-inflammatory, anti-inflammatory cytokines or adipokines. Two authors independently scanned titles and abstracts, and read the studies included. All studies were rated on the PEDro scale and further classified based on American Academy of Neurology criteria. Results: Twelve studies were included of which 10 studies focused on cytokines, 1 study focused on adipokines, and 1 study included both cytokines and adipokines. The selected studies included 3 Class I studies, 7 Class II studies, and 2 Class IV studies and had average PEDro scores of 6.9±1.6. Studies included endurance (n=5), resistance (n=3), combined (n=3), and vibration (n=1) training. Overall, there is a general lack of standardization of procedures across studies and inconsistent evidence for the effects of physical activity and exercise on cytokine and adipokine profiles in MS, with a general pattern indicating a lack of effect. Conclusion: Research regarding the effects of exercise training on cytokines and adipokines in MS is in its infancy, but exercise represents an adjuvant therapy in MS, and future studies are essential for clarifying the role of exercise on cytokines and adipokines in MS.",
author = "Raoof Negaresh and Motl, {Robert W.} and Motahare Mokhtarzade and Ulrik Dalgas and Darpan Patel and Shamsi, {Mehdieh Molanouri} and Nastaran Majdinasab and Rouholah Ranjbar and Philipp Zimmer and Julien Baker",
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Negaresh, R, Motl, RW, Mokhtarzade, M, Dalgas, U, Patel, D, Shamsi, MM, Majdinasab, N, Ranjbar, R, Zimmer, P & Baker, J 2018, 'Effects of exercise training on cytokines and adipokines in multiple sclerosis: a systematic review' Multiple Sclerosis and Related Disorders , vol. 24, pp. 91-100. https://doi.org/10.1016/j.msard.2018.06.008

Effects of exercise training on cytokines and adipokines in multiple sclerosis : a systematic review. / Negaresh, Raoof ; Motl, Robert W.; Mokhtarzade, Motahare ; Dalgas, Ulrik ; Patel, Darpan; Shamsi, Mehdieh Molanouri ; Majdinasab, Nastaran; Ranjbar, Rouholah ; Zimmer, Philipp; Baker, Julien.

In: Multiple Sclerosis and Related Disorders , Vol. 24, 01.08.2018, p. 91-100.

Research output: Contribution to journalArticle

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T1 - Effects of exercise training on cytokines and adipokines in multiple sclerosis

T2 - a systematic review

AU - Negaresh, Raoof

AU - Motl, Robert W.

AU - Mokhtarzade, Motahare

AU - Dalgas, Ulrik

AU - Patel, Darpan

AU - Shamsi, Mehdieh Molanouri

AU - Majdinasab, Nastaran

AU - Ranjbar, Rouholah

AU - Zimmer, Philipp

AU - Baker, Julien

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background: Physical activity, particularly exercise training, is an evidence-based approach for managing symptoms, restoring function and improving overall wellness in people with multiple sclerosis (MS). Several recent studies have argued for a potential disease modifying effect of exercise in people with MS, and among the potential mediating mechanisms are exercise training effects on both cytokines and adipokines. The objectives of this study were to perform a systematic review of exercise training effects on cytokine and adipokine profiles in persons with MS. Methods: We conducted open-dated searches of PubMed, Cochrane Library, EMBASE and PEDro using the terms ‘Multiple sclerosis’ or ‘MS’ AND ‘exercise’ OR ‘training’ OR ‘physical activity’ AND ‘cytokine’ OR ‘inflammatory’ OR ‘immune’ OR ‘adipokine’. Included studies were written in English; comprised of humans with MS, and evaluated the effects of regular physical activity or exercise on pro-inflammatory, anti-inflammatory cytokines or adipokines. Two authors independently scanned titles and abstracts, and read the studies included. All studies were rated on the PEDro scale and further classified based on American Academy of Neurology criteria. Results: Twelve studies were included of which 10 studies focused on cytokines, 1 study focused on adipokines, and 1 study included both cytokines and adipokines. The selected studies included 3 Class I studies, 7 Class II studies, and 2 Class IV studies and had average PEDro scores of 6.9±1.6. Studies included endurance (n=5), resistance (n=3), combined (n=3), and vibration (n=1) training. Overall, there is a general lack of standardization of procedures across studies and inconsistent evidence for the effects of physical activity and exercise on cytokine and adipokine profiles in MS, with a general pattern indicating a lack of effect. Conclusion: Research regarding the effects of exercise training on cytokines and adipokines in MS is in its infancy, but exercise represents an adjuvant therapy in MS, and future studies are essential for clarifying the role of exercise on cytokines and adipokines in MS.

AB - Background: Physical activity, particularly exercise training, is an evidence-based approach for managing symptoms, restoring function and improving overall wellness in people with multiple sclerosis (MS). Several recent studies have argued for a potential disease modifying effect of exercise in people with MS, and among the potential mediating mechanisms are exercise training effects on both cytokines and adipokines. The objectives of this study were to perform a systematic review of exercise training effects on cytokine and adipokine profiles in persons with MS. Methods: We conducted open-dated searches of PubMed, Cochrane Library, EMBASE and PEDro using the terms ‘Multiple sclerosis’ or ‘MS’ AND ‘exercise’ OR ‘training’ OR ‘physical activity’ AND ‘cytokine’ OR ‘inflammatory’ OR ‘immune’ OR ‘adipokine’. Included studies were written in English; comprised of humans with MS, and evaluated the effects of regular physical activity or exercise on pro-inflammatory, anti-inflammatory cytokines or adipokines. Two authors independently scanned titles and abstracts, and read the studies included. All studies were rated on the PEDro scale and further classified based on American Academy of Neurology criteria. Results: Twelve studies were included of which 10 studies focused on cytokines, 1 study focused on adipokines, and 1 study included both cytokines and adipokines. The selected studies included 3 Class I studies, 7 Class II studies, and 2 Class IV studies and had average PEDro scores of 6.9±1.6. Studies included endurance (n=5), resistance (n=3), combined (n=3), and vibration (n=1) training. Overall, there is a general lack of standardization of procedures across studies and inconsistent evidence for the effects of physical activity and exercise on cytokine and adipokine profiles in MS, with a general pattern indicating a lack of effect. Conclusion: Research regarding the effects of exercise training on cytokines and adipokines in MS is in its infancy, but exercise represents an adjuvant therapy in MS, and future studies are essential for clarifying the role of exercise on cytokines and adipokines in MS.

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DO - 10.1016/j.msard.2018.06.008

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JO - Multiple Sclerosis and Related Disorders

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