Effects of cannabis use and subclinical depression on the P3 event-related potential in an emotion processing task

Lucy J. Troup, Robert D. Torrence, Jeremy A. Andrzejewski, Jacob T. Braunwalder

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of residual cannabis use on emotional expression recognition and the P3 event-related potential in participants who scored highly for subclinical depression were investigated. Comparisons were made between participants who were classified as depressed or nondepressed cannabis users, depressed non-cannabis users and controls who neither used cannabis nor were characterized as being depressed. In an emotional expression recognition task, participants were asked to respond to faces depicting happy, angry, fearful, and neutral faces either implicitly, explicitly, or empathically. Residual cannabis use and mood was shown to modulate the P3 event related potential during the task. There was a significant reduction in the P3 amplitude between depressed and nondepressed participants. Residual cannabis use further reduced the P3 amplitude with the greatest deficits being associated with cannabis users who scored highly for subclinical depression. These effects were greatest for explicit and empathic processing of faces depicting negative emotions. We conclude from our study that cannabis and mood state interact to reduce the amplitude of the P3 which has been associated with attention to emotion.

Original languageEnglish
Article numbere6385
JournalMedicine
Volume96
Issue number12
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

    Fingerprint

Keywords

  • Attention
  • Brain
  • Depression
  • Electroencephalography
  • Emotions
  • Event-Related Potentials, P300
  • Facial Recognition
  • Humans
  • Marijuana Smoking
  • Neuropsychological Tests
  • Recognition (Psychology)
  • Journal Article
  • Observational Study

Cite this