Effectiveness of national and subnational infection prevention and control interventions in high-income and upper-middle-income countries: a systematic review

Lesley Price, Jennifer MacDonald, Lynn Melone, Tracey Howe, Paul Flowers, Kay Currie, Evonne Curran, Valerie Ness, Debbie Waddell, Sarkis Manoukian, Agi McFarland, Claire Kilpatrick, Julie Storr, Anthony Twyman, Benedetta Allegranzi, Jacqui Reilly

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Abstract

Evidence-based guidance for national infection prevention and control (IPC) programmes is needed to support national and global capacity building to reduce health-care-associated infection and antimicrobial resistance. In this systematic review we investigate evidence on the effectiveness of IPC interventions implemented at national or subnational levels to inform the development of WHO guidelines on the core components of national IPC programmes. We searched CENTRAL, CINAHL, Embase, MEDLINE, and WHO IRIS databases for publications between Jan 1, 2000, and April 19, 2017. 29 studies that met the eligibility criteria (ie, economic evaluations, cluster-randomised trials, non-randomised trials, controlled before-and-after studies, and interrupted time-series studies exploring the effective of these interventions) were categorised according to intervention type: multimodal, care bundles, policies, and surveillance, monitoring, and feedback. Evidence of effectiveness was found in all categories but the best quality evidence was on multimodal interventions and surveillance, monitoring, and feedback. We call for improvements in study design, reporting of research, and quality of evidence particularly from low-income countries, to strengthen the uptake and international relevance of IPC interventions.
Original languageEnglish
Pages (from-to)E159-E171
Number of pages13
JournalThe Lancet Infectious Diseases
Volume18
Issue number5
Early online date31 Oct 2017
DOIs
Publication statusPublished - 1 May 2018
Externally publishedYes

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Infection Control
Patient Care Bundles
Capacity Building
Cross Infection
MEDLINE
Cost-Benefit Analysis
Publications
Research Design
Databases
Guidelines

Keywords

  • Infection Prevention
  • Systematic review

Cite this

Price, Lesley ; MacDonald, Jennifer ; Melone, Lynn ; Howe, Tracey ; Flowers, Paul ; Currie, Kay ; Curran, Evonne ; Ness, Valerie ; Waddell, Debbie ; Manoukian, Sarkis ; McFarland, Agi ; Kilpatrick, Claire ; Storr, Julie ; Twyman, Anthony ; Allegranzi, Benedetta ; Reilly, Jacqui. / Effectiveness of national and subnational infection prevention and control interventions in high-income and upper-middle-income countries : a systematic review. In: The Lancet Infectious Diseases. 2018 ; Vol. 18, No. 5. pp. E159-E171.
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Price, L, MacDonald, J, Melone, L, Howe, T, Flowers, P, Currie, K, Curran, E, Ness, V, Waddell, D, Manoukian, S, McFarland, A, Kilpatrick, C, Storr, J, Twyman, A, Allegranzi, B & Reilly, J 2018, 'Effectiveness of national and subnational infection prevention and control interventions in high-income and upper-middle-income countries: a systematic review' The Lancet Infectious Diseases, vol. 18, no. 5, pp. E159-E171. https://doi.org/10.1016/S1473-3099(17)30479-6

Effectiveness of national and subnational infection prevention and control interventions in high-income and upper-middle-income countries : a systematic review. / Price, Lesley; MacDonald, Jennifer ; Melone, Lynn; Howe, Tracey; Flowers, Paul; Currie, Kay; Curran, Evonne; Ness, Valerie ; Waddell, Debbie; Manoukian, Sarkis; McFarland, Agi; Kilpatrick, Claire; Storr, Julie; Twyman, Anthony; Allegranzi, Benedetta; Reilly, Jacqui.

In: The Lancet Infectious Diseases, Vol. 18, No. 5, 01.05.2018, p. E159-E171.

Research output: Contribution to journalArticle

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AU - Flowers, Paul

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AU - Ness, Valerie

AU - Waddell, Debbie

AU - Manoukian, Sarkis

AU - McFarland, Agi

AU - Kilpatrick, Claire

AU - Storr, Julie

AU - Twyman, Anthony

AU - Allegranzi, Benedetta

AU - Reilly, Jacqui

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