Effective treatment and prevention of attempted suicide, anxiety, and aggressiveness with fluoxetine, despite proven use of androgenic anabolic steroids

Julio M.X. Amaral*, Monica C. Padilha, Silvana V. Chagas, Julien S. Baker, Carrie Mullen, Leonardo Vieira Neto, Francisco R. Aquino Neto, Marcelo S. Cruz

*Corresponding author for this work

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The treatment of a man who attempted suicide after experiencing symptoms of anxiety and aggressiveness associated with the use of androgenic‐anabolic steroids (AAS) is described. This report includes 30 days of inpatient treatment and a 6‐month follow‐up. Regular use of fluoxetine apparently prevented the onset of anxiety, depression, aggressiveness, and suicide ideation, even with the concurrent use of AAS. The urinary concentration of androgens, metabolites of AAS, and fluoxetine were monitored through analysis of urinary samples by the Brazilian Laboratory of Doping Control. Our results are congruent with previous findings describing the risk of suicide prompted by AAS use as well as the efficacy of fluoxetine in the treatment of mood disorders associated with the use of anabolic steroids.
Original languageEnglish
Article number2912
Pages (from-to)197-202
Number of pages6
JournalDrug Testing and Analysis
Issue number1
Early online date17 Aug 2020
Publication statusE-pub ahead of print - 17 Aug 2020


  • anabolic androgenic steroids
  • androgens
  • attempted suicide
  • mass spectrometry
  • performance-enhancing drugs

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