Effect of helium breathing on intercostal and quadriceps muscle blood flow during exercise in COPD patients

Ioannis Vogiatzis, Helmut Habazettl, Andrea Aliverti, Dimitris Athanasopoulos, Zafeiris Louvaris, Antonella LoMauro, Harrieth Wagner, Charis Roussos, Peter D. Wagner, Spyros Zakynthinos

Research output: Contribution to journalArticle

Abstract

Emerging evidence indicates that, besides dyspnea relief, an improvement in locomotor muscle oxygen delivery may also contribute to enhanced exercise tolerance following normoxic heliox (replacement of inspired nitrogen by helium) administration in patients with chronic obstructive pulmonary disease (COPD). Whether blood flow redistribution from intercostal to locomotor muscles contributes to this improvement currently remains unknown. Accordingly, the objective of this study was to investigate whether such redistribution plays a role in improving locomotor muscle oxygen delivery while breathing heliox at near-maximal [75% peak work rate (WRpeak)], maximal (100% WRpeak), and supramaximal (115% WRpeak) exercise in COPD. Intercostal and vastus lateralis muscle perfusion was measured in 10 COPD patients (FEV1 = 50.5 +/- 5.5% predicted) by near-infrared spectroscopy using indocyanine green dye. Patients undertook exercise tests at 75 and 100% WRpeak breathing either air or heliox and at 115% WRpeak breathing heliox only. Patients did not exhibit exercise-induced hyperinflation. Normoxic heliox reduced respiratory muscle work and relieved dyspnea across all exercise intensities. During near-maximal exercise, quadriceps and intercostal muscle blood flows were greater, while breathing normoxic heliox compared with air (35.8 +/- 7.0 vs. 29.0 +/- 6.5 and 6.0 +/- 1.3 vs. 4.9 +/- 1.2 ml.min(-1).100 g(-1), respectively; P < 0.05; mean +/- SE). In addition, compared with air, normoxic heliox administration increased arterial oxygen content, as well as oxygen delivery to quadriceps and intercostal muscles (from 47 +/- 9 to 60 +/- 12, and from 8 +/- 1 to 13 +/- 3 mlO(2).min(-1).100 g(-1), respectively; P < 0.05). In contrast, normoxic heliox had neither an effect on systemic nor an effect on quadriceps or intercostal muscle blood flow and oxygen delivery during maximal or supramaximal exercise. Since intercostal muscle blood flow did not decrease by normoxic heliox administration, blood flow redistribution from intercostal to locomotor muscles does not represent a likely mechanism of improvement in locomotor muscle oxygen delivery. Our findings might not be applicable to patients who hyperinflate during exercise.
Original languageEnglish
Pages (from-to)R1549-R1559
Number of pages11
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume300
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Keywords

  • work of breathing
  • near-infrared spectroscopy
  • cardiac output
  • muscle oxygen delivery
  • respiratory muscle blood flow

Cite this

Vogiatzis, Ioannis ; Habazettl, Helmut ; Aliverti, Andrea ; Athanasopoulos, Dimitris ; Louvaris, Zafeiris ; LoMauro, Antonella ; Wagner, Harrieth ; Roussos, Charis ; Wagner, Peter D. ; Zakynthinos, Spyros. / Effect of helium breathing on intercostal and quadriceps muscle blood flow during exercise in COPD patients. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2011 ; Vol. 300, No. 6. pp. R1549-R1559.
@article{645ca138dcb84661a757887eeeace46b,
title = "Effect of helium breathing on intercostal and quadriceps muscle blood flow during exercise in COPD patients",
abstract = "Emerging evidence indicates that, besides dyspnea relief, an improvement in locomotor muscle oxygen delivery may also contribute to enhanced exercise tolerance following normoxic heliox (replacement of inspired nitrogen by helium) administration in patients with chronic obstructive pulmonary disease (COPD). Whether blood flow redistribution from intercostal to locomotor muscles contributes to this improvement currently remains unknown. Accordingly, the objective of this study was to investigate whether such redistribution plays a role in improving locomotor muscle oxygen delivery while breathing heliox at near-maximal [75{\%} peak work rate (WRpeak)], maximal (100{\%} WRpeak), and supramaximal (115{\%} WRpeak) exercise in COPD. Intercostal and vastus lateralis muscle perfusion was measured in 10 COPD patients (FEV1 = 50.5 +/- 5.5{\%} predicted) by near-infrared spectroscopy using indocyanine green dye. Patients undertook exercise tests at 75 and 100{\%} WRpeak breathing either air or heliox and at 115{\%} WRpeak breathing heliox only. Patients did not exhibit exercise-induced hyperinflation. Normoxic heliox reduced respiratory muscle work and relieved dyspnea across all exercise intensities. During near-maximal exercise, quadriceps and intercostal muscle blood flows were greater, while breathing normoxic heliox compared with air (35.8 +/- 7.0 vs. 29.0 +/- 6.5 and 6.0 +/- 1.3 vs. 4.9 +/- 1.2 ml.min(-1).100 g(-1), respectively; P < 0.05; mean +/- SE). In addition, compared with air, normoxic heliox administration increased arterial oxygen content, as well as oxygen delivery to quadriceps and intercostal muscles (from 47 +/- 9 to 60 +/- 12, and from 8 +/- 1 to 13 +/- 3 mlO(2).min(-1).100 g(-1), respectively; P < 0.05). In contrast, normoxic heliox had neither an effect on systemic nor an effect on quadriceps or intercostal muscle blood flow and oxygen delivery during maximal or supramaximal exercise. Since intercostal muscle blood flow did not decrease by normoxic heliox administration, blood flow redistribution from intercostal to locomotor muscles does not represent a likely mechanism of improvement in locomotor muscle oxygen delivery. Our findings might not be applicable to patients who hyperinflate during exercise.",
keywords = "work of breathing, near-infrared spectroscopy, cardiac output, muscle oxygen delivery, respiratory muscle blood flow",
author = "Ioannis Vogiatzis and Helmut Habazettl and Andrea Aliverti and Dimitris Athanasopoulos and Zafeiris Louvaris and Antonella LoMauro and Harrieth Wagner and Charis Roussos and Wagner, {Peter D.} and Spyros Zakynthinos",
year = "2011",
month = "6",
doi = "10.1152/ajpregu.00671.2010",
language = "English",
volume = "300",
pages = "R1549--R1559",
journal = "American Journal of Physiology - Regulatory Integrative and Comparative Physiology",
issn = "0363-6119",
publisher = "The American Physiological Society",
number = "6",

}

Effect of helium breathing on intercostal and quadriceps muscle blood flow during exercise in COPD patients. / Vogiatzis, Ioannis; Habazettl, Helmut; Aliverti, Andrea; Athanasopoulos, Dimitris; Louvaris, Zafeiris; LoMauro, Antonella; Wagner, Harrieth; Roussos, Charis; Wagner, Peter D.; Zakynthinos, Spyros.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 300, No. 6, 06.2011, p. R1549-R1559.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of helium breathing on intercostal and quadriceps muscle blood flow during exercise in COPD patients

AU - Vogiatzis, Ioannis

AU - Habazettl, Helmut

AU - Aliverti, Andrea

AU - Athanasopoulos, Dimitris

AU - Louvaris, Zafeiris

AU - LoMauro, Antonella

AU - Wagner, Harrieth

AU - Roussos, Charis

AU - Wagner, Peter D.

AU - Zakynthinos, Spyros

PY - 2011/6

Y1 - 2011/6

N2 - Emerging evidence indicates that, besides dyspnea relief, an improvement in locomotor muscle oxygen delivery may also contribute to enhanced exercise tolerance following normoxic heliox (replacement of inspired nitrogen by helium) administration in patients with chronic obstructive pulmonary disease (COPD). Whether blood flow redistribution from intercostal to locomotor muscles contributes to this improvement currently remains unknown. Accordingly, the objective of this study was to investigate whether such redistribution plays a role in improving locomotor muscle oxygen delivery while breathing heliox at near-maximal [75% peak work rate (WRpeak)], maximal (100% WRpeak), and supramaximal (115% WRpeak) exercise in COPD. Intercostal and vastus lateralis muscle perfusion was measured in 10 COPD patients (FEV1 = 50.5 +/- 5.5% predicted) by near-infrared spectroscopy using indocyanine green dye. Patients undertook exercise tests at 75 and 100% WRpeak breathing either air or heliox and at 115% WRpeak breathing heliox only. Patients did not exhibit exercise-induced hyperinflation. Normoxic heliox reduced respiratory muscle work and relieved dyspnea across all exercise intensities. During near-maximal exercise, quadriceps and intercostal muscle blood flows were greater, while breathing normoxic heliox compared with air (35.8 +/- 7.0 vs. 29.0 +/- 6.5 and 6.0 +/- 1.3 vs. 4.9 +/- 1.2 ml.min(-1).100 g(-1), respectively; P < 0.05; mean +/- SE). In addition, compared with air, normoxic heliox administration increased arterial oxygen content, as well as oxygen delivery to quadriceps and intercostal muscles (from 47 +/- 9 to 60 +/- 12, and from 8 +/- 1 to 13 +/- 3 mlO(2).min(-1).100 g(-1), respectively; P < 0.05). In contrast, normoxic heliox had neither an effect on systemic nor an effect on quadriceps or intercostal muscle blood flow and oxygen delivery during maximal or supramaximal exercise. Since intercostal muscle blood flow did not decrease by normoxic heliox administration, blood flow redistribution from intercostal to locomotor muscles does not represent a likely mechanism of improvement in locomotor muscle oxygen delivery. Our findings might not be applicable to patients who hyperinflate during exercise.

AB - Emerging evidence indicates that, besides dyspnea relief, an improvement in locomotor muscle oxygen delivery may also contribute to enhanced exercise tolerance following normoxic heliox (replacement of inspired nitrogen by helium) administration in patients with chronic obstructive pulmonary disease (COPD). Whether blood flow redistribution from intercostal to locomotor muscles contributes to this improvement currently remains unknown. Accordingly, the objective of this study was to investigate whether such redistribution plays a role in improving locomotor muscle oxygen delivery while breathing heliox at near-maximal [75% peak work rate (WRpeak)], maximal (100% WRpeak), and supramaximal (115% WRpeak) exercise in COPD. Intercostal and vastus lateralis muscle perfusion was measured in 10 COPD patients (FEV1 = 50.5 +/- 5.5% predicted) by near-infrared spectroscopy using indocyanine green dye. Patients undertook exercise tests at 75 and 100% WRpeak breathing either air or heliox and at 115% WRpeak breathing heliox only. Patients did not exhibit exercise-induced hyperinflation. Normoxic heliox reduced respiratory muscle work and relieved dyspnea across all exercise intensities. During near-maximal exercise, quadriceps and intercostal muscle blood flows were greater, while breathing normoxic heliox compared with air (35.8 +/- 7.0 vs. 29.0 +/- 6.5 and 6.0 +/- 1.3 vs. 4.9 +/- 1.2 ml.min(-1).100 g(-1), respectively; P < 0.05; mean +/- SE). In addition, compared with air, normoxic heliox administration increased arterial oxygen content, as well as oxygen delivery to quadriceps and intercostal muscles (from 47 +/- 9 to 60 +/- 12, and from 8 +/- 1 to 13 +/- 3 mlO(2).min(-1).100 g(-1), respectively; P < 0.05). In contrast, normoxic heliox had neither an effect on systemic nor an effect on quadriceps or intercostal muscle blood flow and oxygen delivery during maximal or supramaximal exercise. Since intercostal muscle blood flow did not decrease by normoxic heliox administration, blood flow redistribution from intercostal to locomotor muscles does not represent a likely mechanism of improvement in locomotor muscle oxygen delivery. Our findings might not be applicable to patients who hyperinflate during exercise.

KW - work of breathing

KW - near-infrared spectroscopy

KW - cardiac output

KW - muscle oxygen delivery

KW - respiratory muscle blood flow

U2 - 10.1152/ajpregu.00671.2010

DO - 10.1152/ajpregu.00671.2010

M3 - Article

VL - 300

SP - R1549-R1559

JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

SN - 0363-6119

IS - 6

ER -