Effect of exercise intensity and duration on cardiac troponin release

Lucy Marshall; Kuan Ken Lee; Stacey D. Stewart; Adam Wild; Takeshi Fujisawa; Amy V. Ferry; Catherine L. Stables; Hannah Lithgow; Andrew R. Chapman; Atul Anand; Anoop S.V. Shah; Neeraj Dhaun; Fiona E. Strachan; Nicholas L. Mills; Mark D. Ross

doi:10.1161/CIRCULATIONAHA.119.041874

Effect of exercise intensity and duration on cardiac troponin release

Lucy Marshall, Kuan Ken Lee, Stacey D. Stewart, Adam Wild, Takeshi Fujisawa, Amy V. Ferry, Catherine L. Stables, Hannah Lithgow, Andrew R. Chapman, Atul Anand, Anoop S.V. Shah, Neeraj Dhaun, Fiona E. Strachan, Nicholas L. Mills^*, Mark D. Ross

^*Corresponding author for this work

School of Health and Life Sciences

Research output: Contribution to journal › Letter › peer-review

27 Citations (Scopus)

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Abstract

The latest generation of high-sensitivity cardiac troponin assays are able to quantify very low concentrations of troponin in the majority of people. Indeed, international guidelines now recommend the use of low concentrations of troponin to risk-stratify patients with suspected acute coronary syndrome.¹ Furthermore, troponin is an independent predictor of cardiovascular events in apparently healthy populations, and therefore, concentrations within the reference range may have a wider role in guiding the use of preventative therapies.² However, troponin can become significantly elevated after physical exercise. Interpreting troponin concentrations in this context is challenging because the kinetics of troponin release after physical exercise are not well understood. Most previous research has used assays that are not able to quantify troponin within the reference range, or has involved endurance athletes and evaluated a single time point rather than serial sampling.³

Original language	English
Pages (from-to)	83-85
Number of pages	3
Journal	Circulation
Volume	141
Issue number	1
Early online date	30 Dec 2019
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.119.041874
Publication status	Published - 7 Jan 2020

Keywords

physical exercise
troponin

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2019 10 15 Marshall et al Exercise finalFinal published version, 247 KBLicence: CC BY

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@article{32471bc26c96478a986991d792132f6e,

title = "Effect of exercise intensity and duration on cardiac troponin release",

abstract = "The latest generation of high-sensitivity cardiac troponin assays are able to quantify very low concentrations of troponin in the majority of people. Indeed, international guidelines now recommend the use of low concentrations of troponin to risk-stratify patients with suspected acute coronary syndrome.1 Furthermore, troponin is an independent predictor of cardiovascular events in apparently healthy populations, and therefore, concentrations within the reference range may have a wider role in guiding the use of preventative therapies.2 However, troponin can become significantly elevated after physical exercise. Interpreting troponin concentrations in this context is challenging because the kinetics of troponin release after physical exercise are not well understood. Most previous research has used assays that are not able to quantify troponin within the reference range, or has involved endurance athletes and evaluated a single time point rather than serial sampling.3",

keywords = "physical exercise, troponin",

author = "Lucy Marshall and Lee, {Kuan Ken} and Stewart, {Stacey D.} and Adam Wild and Takeshi Fujisawa and Ferry, {Amy V.} and Stables, {Catherine L.} and Hannah Lithgow and Chapman, {Andrew R.} and Atul Anand and Shah, {Anoop S.V.} and Neeraj Dhaun and Strachan, {Fiona E.} and Mills, {Nicholas L.} and Ross, {Mark D.}",

year = "2020",

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doi = "10.1161/CIRCULATIONAHA.119.041874",

language = "English",

volume = "141",

pages = "83--85",

journal = "Circulation",

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TY - JOUR

T1 - Effect of exercise intensity and duration on cardiac troponin release

AU - Marshall, Lucy

AU - Lee, Kuan Ken

AU - Stewart, Stacey D.

AU - Wild, Adam

AU - Fujisawa, Takeshi

AU - Ferry, Amy V.

AU - Stables, Catherine L.

AU - Lithgow, Hannah

AU - Chapman, Andrew R.

AU - Anand, Atul

AU - Shah, Anoop S.V.

AU - Dhaun, Neeraj

AU - Strachan, Fiona E.

AU - Mills, Nicholas L.

AU - Ross, Mark D.

PY - 2020/1/7

Y1 - 2020/1/7

N2 - The latest generation of high-sensitivity cardiac troponin assays are able to quantify very low concentrations of troponin in the majority of people. Indeed, international guidelines now recommend the use of low concentrations of troponin to risk-stratify patients with suspected acute coronary syndrome.1 Furthermore, troponin is an independent predictor of cardiovascular events in apparently healthy populations, and therefore, concentrations within the reference range may have a wider role in guiding the use of preventative therapies.2 However, troponin can become significantly elevated after physical exercise. Interpreting troponin concentrations in this context is challenging because the kinetics of troponin release after physical exercise are not well understood. Most previous research has used assays that are not able to quantify troponin within the reference range, or has involved endurance athletes and evaluated a single time point rather than serial sampling.3

AB - The latest generation of high-sensitivity cardiac troponin assays are able to quantify very low concentrations of troponin in the majority of people. Indeed, international guidelines now recommend the use of low concentrations of troponin to risk-stratify patients with suspected acute coronary syndrome.1 Furthermore, troponin is an independent predictor of cardiovascular events in apparently healthy populations, and therefore, concentrations within the reference range may have a wider role in guiding the use of preventative therapies.2 However, troponin can become significantly elevated after physical exercise. Interpreting troponin concentrations in this context is challenging because the kinetics of troponin release after physical exercise are not well understood. Most previous research has used assays that are not able to quantify troponin within the reference range, or has involved endurance athletes and evaluated a single time point rather than serial sampling.3

KW - physical exercise

KW - troponin

U2 - 10.1161/CIRCULATIONAHA.119.041874

DO - 10.1161/CIRCULATIONAHA.119.041874

M3 - Letter

C2 - 31887079

AN - SCOPUS:85077320624

SN - 0009-7322

VL - 141

SP - 83

EP - 85

JO - Circulation

JF - Circulation

IS - 1

ER -

Effect of exercise intensity and duration on cardiac troponin release

Abstract

Keywords

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