Abstract
OBJECTIVE: To investigate the effect of cyclosporin A (CyA) therapy on circulating concentrations of interleukin-6 (IL-6) and soluble interleukin-2 receptor (sIL-2R) in patients with rheumatoid arthritis (RA).
METHODS: Twenty four RA patients with active disease were studied. Plasma was collected before and after 16 weeks of CyA treatment. IL-6 was measured by B9 bioassay and sIL-2R by enzyme linked immunosorbent assay (ELISA).
RESULTS: The initial median IL-6 concentration of 165 IU/ml decreased significantly to 71 IU/ml after 16 weeks (p < 0.05). Similarly, the initial median plasma sIL-2R value of 665 U/ml decreased significantly to 570 U/ml (p < 0.05). This decrease was accompanied by an improvement in clinical parameters of disease activity. Some association between sIL-2R, IL-6, haemoglobin, and platelets was also observed.
CONCLUSIONS: This study has demonstrated that, in vivo, CyA therapy in RA can significantly reduce circulating concentrations of IL-6 and sIL-2R. Modulation of both T and non-T cell derived cytokines may be one mechanism by which CyA improves rheumatoid disease. Whether this is a direct effect of CyA on the cells within the rheumatoid joint producing these cytokines or an indirect effect mediated by other cytokines which can influence IL-6 and Il-2R values remains to be determined.
Original language | English |
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Pages (from-to) | 137-9 |
Number of pages | 3 |
Journal | Annals of the Rheumatic Diseases |
Volume | 54 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 1995 |
Externally published | Yes |
Keywords
- Adult
- Aged
- Arthritis, Rheumatoid
- Cyclosporine
- Female
- Hemoglobins
- Humans
- Interleukin-6
- Male
- Middle Aged
- Platelet Count
- Prospective Studies
- Receptors, Interleukin-2