TY - JOUR
T1 - Effect of a lifestyle intervention on telomere length
T2 - a systematic review and meta-analysis
AU - Buttet, Marjorie
AU - Bagheri, Reza
AU - Ugbolue, Ukadike C.
AU - Laporte, Catherine
AU - Trousselard, Marion
AU - Benson, Amanda
AU - Bouillon-Minois, Jean Baptiste
AU - Dutheil, Frédéric
PY - 2022/9/30
Y1 - 2022/9/30
N2 - Background: We conducted a systematic review and meta-analysis to assess the effects of lifestyle intervention on telomere length (TL). Method: Four databases were searched for studies reporting TL in leukocytes, before and after a lifestyle intervention. We computed random-effects meta-analysis on TL within intervention and control group after versus before intervention, and on changes in TL between groups. Sensitivity analyses and Meta-regression were conducted. Results: We included 20 studies in the systematic review (2995 participants, mean 50.3 years old, 77% women, 2045 following an intervention and 950 controls) and 19 in the meta-analysis. TL were similar at baseline between intervention and control groups. The physical activity ± diet group had an increase in TL (Effect size 0.17, 95%CI 0.03–0.31, p = 0.020) using changes within the intervention group, whereas TL shortened in the control group (−0.32, −0.61 to −0.02, p = 0.037). TL was longer in the physical activity ± diet intervention group (0.24, 0.08–0.40, p = 0.004) compared to controls after the intervention. Sensitivity analysis gave similar results. Meta-regressions demonstrated that combining strength and endurance exercise increased TL more than endurance alone or strength alone. Conclusion: A lifestyle intervention with physical activity ± diet can increase telomere length, independently of population characteristics or baseline TL.
AB - Background: We conducted a systematic review and meta-analysis to assess the effects of lifestyle intervention on telomere length (TL). Method: Four databases were searched for studies reporting TL in leukocytes, before and after a lifestyle intervention. We computed random-effects meta-analysis on TL within intervention and control group after versus before intervention, and on changes in TL between groups. Sensitivity analyses and Meta-regression were conducted. Results: We included 20 studies in the systematic review (2995 participants, mean 50.3 years old, 77% women, 2045 following an intervention and 950 controls) and 19 in the meta-analysis. TL were similar at baseline between intervention and control groups. The physical activity ± diet group had an increase in TL (Effect size 0.17, 95%CI 0.03–0.31, p = 0.020) using changes within the intervention group, whereas TL shortened in the control group (−0.32, −0.61 to −0.02, p = 0.037). TL was longer in the physical activity ± diet intervention group (0.24, 0.08–0.40, p = 0.004) compared to controls after the intervention. Sensitivity analysis gave similar results. Meta-regressions demonstrated that combining strength and endurance exercise increased TL more than endurance alone or strength alone. Conclusion: A lifestyle intervention with physical activity ± diet can increase telomere length, independently of population characteristics or baseline TL.
KW - aging
KW - behavior
KW - biology
KW - exercise
KW - genetic
KW - public health
UR - http://www.scopus.com/inward/record.url?scp=85132928230&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2022.111694
DO - 10.1016/j.mad.2022.111694
M3 - Article
AN - SCOPUS:85132928230
SN - 0047-6374
VL - 206
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
M1 - 111694
ER -
