Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections

Craig W Roberts, Fiona L Henriquez

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

New more efficacious antimicrobials as required for the treatment of Acanthamoeba infections as those currently available require arduous treatment regimes, are not always effective and are poorly active against the cystic stages. Herein, we review potential drug targets including tubulin, alternative oxidase, amino acid biosynthesis and myosin. In addition, we review the literature for current missing tools and resources for the identification, validation and development of new antimicrobials for this organism. Additional targets should come to light through a concerted genome sequencing effort.

Original languageEnglish
Pages (from-to)91-6
Number of pages6
JournalExperimental Parasitology
Volume126
Issue number1
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Acanthamoeba
  • Amebiasis
  • Animals
  • Antiprotozoal Agents
  • Cellulose
  • Cytoskeletal Proteins
  • Disease Models, Animal
  • Humans
  • Mitochondrial Proteins
  • Ornithine Decarboxylase
  • Oxidoreductases
  • Plant Proteins

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