Do distinct atypical cortical networks process biological motion information in adults with Autism Spectrum Disorders?

Lawrie McKay, David Simmons, Phil McAleer, Dominic Marjoram, Judith Piggot, Frank Pollick

Research output: Contribution to journalArticle

Abstract

Whether people with Autism Spectrum Disorders (ASDs) have a specific deficit when processing biological motion has been a topic of much debate. We used psychophysical methods to determine individual behavioural thresholds in a point-light direction discrimination paradigm for a small but carefully matched groups of adults (N=10 per group) with and without ASDs. These thresholds were used to derive individual stimulus levels in an identical fMRI task, with the purpose of equalising task performance across all participants whilst inside the scanner. The results of this investigation show that despite comparable behavioural performance both inside and outside the scanner, the group with ASDs shows a different pattern of BOLD activation from the TD group in response to the same stimulus levels. Furthermore, connectivity analysis suggests that the main differences between the groups are that the TD group utilise a unitary network with information passing from temporal to parietal regions, whilst the ASD group utilise two distinct networks; one utilising motion sensitive areas and another utilising form selective areas. Furthermore, a temporal-parietal link that is present in the TD group is missing in the ASD group. We tentatively propose that these differences may occur due to early dysfunctional connectivity in the brains of people with ASDs, which to some extent is compensated for by rewiring in high functioning adults.
Original languageEnglish
Pages (from-to)1524-1533
Number of pages10
JournalNeuroimage
Volume59
Issue number2
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Biological Phenomena
Parietal Lobe
Information Services
Task Performance and Analysis
Autism Spectrum Disorder
Research Design
Magnetic Resonance Imaging
Light
Brain

Keywords

  • Autism Spectrum Disorders
  • Biological Motion
  • fMRI
  • Connectivity
  • Granger Causality Mapping

Cite this

McKay, Lawrie ; Simmons, David ; McAleer, Phil ; Marjoram, Dominic ; Piggot, Judith ; Pollick, Frank. / Do distinct atypical cortical networks process biological motion information in adults with Autism Spectrum Disorders?. In: Neuroimage. 2012 ; Vol. 59, No. 2. pp. 1524-1533.
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Do distinct atypical cortical networks process biological motion information in adults with Autism Spectrum Disorders? / McKay, Lawrie; Simmons, David; McAleer, Phil; Marjoram, Dominic; Piggot, Judith; Pollick, Frank.

In: Neuroimage, Vol. 59, No. 2, 2012, p. 1524-1533.

Research output: Contribution to journalArticle

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