Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment

Mostafa E. Rateb; Wael E. Houssen; William T. A. Harrison; Hai Deng; Chinyere K. Okoro; Juan A. Asenjo; Barbara A. Andrews; Alan T. Bull; Michael Goodfellow; Rainer Ebel; Marcel Jaspars

doi:10.1021/np200470u

Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment

Mostafa E. Rateb, Wael E. Houssen, William T. A. Harrison, Hai Deng, Chinyere K. Okoro, Juan A. Asenjo, Barbara A. Andrews, Alan T. Bull, Michael Goodfellow, Rainer Ebel, Marcel Jaspars

Research output: Contribution to journal › Article › peer-review

125 Citations (Scopus)

Abstract

The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A–C (1–3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1–3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.

Original language	English
Pages (from-to)	1965-1971
Number of pages	7
Journal	Journal of Natural Products
Volume	74
Issue number	9
DOIs	https://doi.org/10.1021/np200470u
Publication status	Published - 31 Aug 2011
Externally published	Yes

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title = "Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment",

abstract = "The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A–C (1–3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1–3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.",

author = "Rateb, {Mostafa E.} and Houssen, {Wael E.} and Harrison, {William T. A.} and Hai Deng and Okoro, {Chinyere K.} and Asenjo, {Juan A.} and Andrews, {Barbara A.} and Bull, {Alan T.} and Michael Goodfellow and Rainer Ebel and Marcel Jaspars",

year = "2011",

month = aug,

day = "31",

doi = "10.1021/np200470u",

language = "English",

volume = "74",

pages = "1965--1971",

journal = "Journal of Natural Products",

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TY - JOUR

T1 - Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment

AU - Rateb, Mostafa E.

AU - Houssen, Wael E.

AU - Harrison, William T. A.

AU - Deng, Hai

AU - Okoro, Chinyere K.

AU - Asenjo, Juan A.

AU - Andrews, Barbara A.

AU - Bull, Alan T.

AU - Goodfellow, Michael

AU - Ebel, Rainer

AU - Jaspars, Marcel

PY - 2011/8/31

Y1 - 2011/8/31

N2 - The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A–C (1–3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1–3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.

AB - The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A–C (1–3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1–3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.

U2 - 10.1021/np200470u

DO - 10.1021/np200470u

M3 - Article

SN - 0163-3864

VL - 74

SP - 1965

EP - 1971

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment

Abstract

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