Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment

Mostafa E. Rateb, Wael E. Houssen, William T. A. Harrison, Hai Deng, Chinyere K. Okoro, Juan A. Asenjo, Barbara A. Andrews, Alan T. Bull, Michael Goodfellow, Rainer Ebel, Marcel Jaspars

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Abstract

The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A–C (1–3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1–3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.
Original languageEnglish
Pages (from-to)1965-1971
Number of pages7
JournalJournal of Natural Products
Volume74
Issue number9
DOIs
Publication statusPublished - 31 Aug 2011
Externally publishedYes

Cite this

Rateb, M. E., Houssen, W. E., Harrison, W. T. A., Deng, H., Okoro, C. K., Asenjo, J. A., Andrews, B. A., Bull, A. T., Goodfellow, M., Ebel, R., & Jaspars, M. (2011). Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment. Journal of Natural Products, 74(9), 1965-1971. https://doi.org/10.1021/np200470u