Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments

T.G. Truscott, A.J. McLean, A.M.R Phillips, W.S. Foulds

Research output: Contribution to journalArticle

Abstract

The photosensitiser currently used in the photodynamic therapy of cancer is haematoporphyrin derivative. Pulsed laser studies of this material and also of the "parent" molecule haematoporphyrin in polyoma-transformed fibroblast cells have now been studied. We report, for the first time, the observation of the triplet absorption of these sensitisers in cells. The corresponding triplet-triplet spectra are red shifted compared to aqueous…
Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalCancer Letters
Volume41
Issue number1
DOIs
Publication statusPublished - Jul 1988

Fingerprint

Hematoporphyrins
Hematoporphyrin Derivative
Photosensitizing Agents
Photochemotherapy
Lasers
Fibroblasts
Observation
Neoplasms

Keywords

  • Haematoporphyrin
  • Haematoporphyrin derivative
  • Triplet states
  • Singlet oxygen
  • Cellular environments

Cite this

Truscott, T.G. ; McLean, A.J. ; Phillips, A.M.R ; Foulds, W.S. / Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments. In: Cancer Letters. 1988 ; Vol. 41, No. 1. pp. 31-35.
@article{b0525337ddd94e78a5eacd1f810e6e60,
title = "Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments",
abstract = "The photosensitiser currently used in the photodynamic therapy of cancer is haematoporphyrin derivative. Pulsed laser studies of this material and also of the {"}parent{"} molecule haematoporphyrin in polyoma-transformed fibroblast cells have now been studied. We report, for the first time, the observation of the triplet absorption of these sensitisers in cells. The corresponding triplet-triplet spectra are red shifted compared to aqueous…",
keywords = "Haematoporphyrin, Haematoporphyrin derivative, Triplet states, Singlet oxygen, Cellular environments",
author = "T.G. Truscott and A.J. McLean and A.M.R Phillips and W.S. Foulds",
year = "1988",
month = "7",
doi = "10.1016/0304-3835(88)90051-1",
language = "English",
volume = "41",
pages = "31--35",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier B.V.",
number = "1",

}

Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments. / Truscott, T.G.; McLean, A.J.; Phillips, A.M.R; Foulds, W.S.

In: Cancer Letters, Vol. 41, No. 1, 07.1988, p. 31-35.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments

AU - Truscott, T.G.

AU - McLean, A.J.

AU - Phillips, A.M.R

AU - Foulds, W.S.

PY - 1988/7

Y1 - 1988/7

N2 - The photosensitiser currently used in the photodynamic therapy of cancer is haematoporphyrin derivative. Pulsed laser studies of this material and also of the "parent" molecule haematoporphyrin in polyoma-transformed fibroblast cells have now been studied. We report, for the first time, the observation of the triplet absorption of these sensitisers in cells. The corresponding triplet-triplet spectra are red shifted compared to aqueous…

AB - The photosensitiser currently used in the photodynamic therapy of cancer is haematoporphyrin derivative. Pulsed laser studies of this material and also of the "parent" molecule haematoporphyrin in polyoma-transformed fibroblast cells have now been studied. We report, for the first time, the observation of the triplet absorption of these sensitisers in cells. The corresponding triplet-triplet spectra are red shifted compared to aqueous…

KW - Haematoporphyrin

KW - Haematoporphyrin derivative

KW - Triplet states

KW - Singlet oxygen

KW - Cellular environments

U2 - 10.1016/0304-3835(88)90051-1

DO - 10.1016/0304-3835(88)90051-1

M3 - Article

VL - 41

SP - 31

EP - 35

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -