Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments

T.G. Truscott, A.J. McLean, A.M.R Phillips, W.S. Foulds

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Abstract

The photosensitiser currently used in the photodynamic therapy of cancer is haematoporphyrin derivative. Pulsed laser studies of this material and also of the "parent" molecule haematoporphyrin in polyoma-transformed fibroblast cells have now been studied. We report, for the first time, the observation of the triplet absorption of these sensitisers in cells. The corresponding triplet-triplet spectra are red shifted compared to aqueous…
Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalCancer Letters
Volume41
Issue number1
DOIs
Publication statusPublished - Jul 1988

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Keywords

  • Haematoporphyrin
  • Haematoporphyrin derivative
  • Triplet states
  • Singlet oxygen
  • Cellular environments

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