Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments

T.G. Truscott; A.J. McLean; A.M.R Phillips; W.S. Foulds

doi:10.1016/0304-3835(88)90051-1

Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments

T.G. Truscott, A.J. McLean, A.M.R Phillips, W.S. Foulds

School of Health and Life Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The photosensitiser currently used in the photodynamic therapy of cancer is haematoporphyrin derivative. Pulsed laser studies of this material and also of the "parent" molecule haematoporphyrin in polyoma-transformed fibroblast cells have now been studied. We report, for the first time, the observation of the triplet absorption of these sensitisers in cells. The corresponding triplet-triplet spectra are red shifted compared to aqueous…

Original language	English
Pages (from-to)	31-35
Number of pages	5
Journal	Cancer Letters
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(88)90051-1
Publication status	Published - Jul 1988

Keywords

Haematoporphyrin
Haematoporphyrin derivative
Triplet states
Singlet oxygen
Cellular environments

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(88)90051-1

Cite this

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title = "Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments",

abstract = "The photosensitiser currently used in the photodynamic therapy of cancer is haematoporphyrin derivative. Pulsed laser studies of this material and also of the {"}parent{"} molecule haematoporphyrin in polyoma-transformed fibroblast cells have now been studied. We report, for the first time, the observation of the triplet absorption of these sensitisers in cells. The corresponding triplet-triplet spectra are red shifted compared to aqueous…",

keywords = "Haematoporphyrin, Haematoporphyrin derivative, Triplet states, Singlet oxygen, Cellular environments",

author = "T.G. Truscott and A.J. McLean and A.M.R Phillips and W.S. Foulds",

year = "1988",

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doi = "10.1016/0304-3835(88)90051-1",

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T1 - Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments

AU - Truscott, T.G.

AU - McLean, A.J.

AU - Phillips, A.M.R

AU - Foulds, W.S.

PY - 1988/7

Y1 - 1988/7

N2 - The photosensitiser currently used in the photodynamic therapy of cancer is haematoporphyrin derivative. Pulsed laser studies of this material and also of the "parent" molecule haematoporphyrin in polyoma-transformed fibroblast cells have now been studied. We report, for the first time, the observation of the triplet absorption of these sensitisers in cells. The corresponding triplet-triplet spectra are red shifted compared to aqueous…

AB - The photosensitiser currently used in the photodynamic therapy of cancer is haematoporphyrin derivative. Pulsed laser studies of this material and also of the "parent" molecule haematoporphyrin in polyoma-transformed fibroblast cells have now been studied. We report, for the first time, the observation of the triplet absorption of these sensitisers in cells. The corresponding triplet-triplet spectra are red shifted compared to aqueous…

KW - Haematoporphyrin

KW - Haematoporphyrin derivative

KW - Triplet states

KW - Singlet oxygen

KW - Cellular environments

U2 - 10.1016/0304-3835(88)90051-1

DO - 10.1016/0304-3835(88)90051-1

M3 - Article

VL - 41

SP - 31

EP - 35

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments

Abstract

Keywords

UN SDGs

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