Decorosides A and B: Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum

Mostafa Rateb*, Hassan HM, SA el Arafa, Marcel Jaspars, Rainer Ebel

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.
Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalNatutral Product Communications
Volume9
Issue number4
Publication statusPublished - Apr 2014
Externally publishedYes

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Rhododendron
Catechin
Glycosides
Flavonoids
Biological Assay
Cell Line
Neoplasms
decoroside A
decoroside B

Cite this

Rateb, Mostafa ; HM, Hassan ; el Arafa, SA ; Jaspars, Marcel ; Ebel, Rainer. / Decorosides A and B : Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum . In: Natutral Product Communications. 2014 ; Vol. 9, No. 4. pp. 473-476.
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Decorosides A and B : Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum . / Rateb, Mostafa; HM, Hassan; el Arafa, SA; Jaspars, Marcel; Ebel, Rainer.

In: Natutral Product Communications, Vol. 9, No. 4, 04.2014, p. 473-476.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Decorosides A and B

T2 - Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum

AU - Rateb, Mostafa

AU - HM, Hassan

AU - el Arafa, SA

AU - Jaspars, Marcel

AU - Ebel, Rainer

PY - 2014/4

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N2 - Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

AB - Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

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