Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.
|Number of pages||4|
|Journal||Natutral Product Communications|
|Publication status||Published - Apr 2014|
Rateb, M., HM, H., el Arafa, SA., Jaspars, M., & Ebel, R. (2014). Decorosides A and B: Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum . Natutral Product Communications, 9(4), 473-476.