Decorosides A and B: Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum

Mostafa Rateb*, Hassan HM, SA el Arafa, Marcel Jaspars, Rainer Ebel

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.
Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalNatutral Product Communications
Volume9
Issue number4
Publication statusPublished - Apr 2014
Externally publishedYes

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