Decorosides A and B: Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum

Mostafa Rateb; Hassan HM; SA el Arafa; Marcel Jaspars; Rainer Ebel

Decorosides A and B: Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum

Mostafa Rateb^*, Hassan HM, SA el Arafa, Marcel Jaspars, Rainer Ebel

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

Original language	English
Pages (from-to)	473-476
Number of pages	4
Journal	Natutral Product Communications
Volume	9
Issue number	4
Publication status	Published - Apr 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{cc0f6465b6494621ad319c88c628f8d6,

title = "Decorosides A and B: Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum ",

abstract = "Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.",

author = "Mostafa Rateb and Hassan HM and {el Arafa}, SA and Marcel Jaspars and Rainer Ebel",

year = "2014",

month = apr,

language = "English",

volume = "9",

pages = "473--476",

journal = "Natutral Product Communications",

issn = "1555-9475",

publisher = "Natural Product Communications",

number = "4",

}

TY - JOUR

T1 - Decorosides A and B

T2 - Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum

AU - Rateb, Mostafa

AU - HM, Hassan

AU - el Arafa, SA

AU - Jaspars, Marcel

AU - Ebel, Rainer

PY - 2014/4

Y1 - 2014/4

N2 - Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

AB - Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against different cancer cell lines.

M3 - Article

SN - 1555-9475

VL - 9

SP - 473

EP - 476

JO - Natutral Product Communications

JF - Natutral Product Communications

IS - 4

ER -

Decorosides A and B: Cytotoxic flavonoid glycosides from the leaves of rhododendron decorum

Abstract

UN SDGs

Fingerprint

Cite this