Comparison of albendazole and levamisole chemotherapy on prevalence and intensity of common soil-transmitted helminth infections in school children, Sierra Leone

R A Williams, M M Koroma, M Hodges

Research output: Contribution to journalArticle

Abstract

A comparison of two studies performed in Sierra Leone on the effect of anthelmintic, chemotherapy, levamisole, albendazole or a placebo in children aged 6 to 10 years on the prevalence and intensity of common soil transmitted helminths (S-THs) infections is presented. In total 501 children were screened, and 394 successfully follow-up. At baseline their overall prevalence and intensity (epg) of Ascaris, Necator and Trichuris were 34% (2,877), 22% (284) and 39% (266) respectively. At baseline there was no significant difference in the intensity of S-THs infections in the different treatment groups but the prevalence of Necator was significantly higher in the levamisole than the albendazole group (p < 0.05). At follow-up both albendazole and levamisole significantly reduced prevalence and intensity of Ascaris and Trichuris. Only albendazole significantly reduced those of Necator. The placebo group had no significant change in prevalence but a significant increase in intensity of all S-THs.

Original languageEnglish
Pages (from-to)179-83
Number of pages5
JournalWest African Journal of Medicine
Volume16
Issue number3
Publication statusPublished - 1 Jul 1997
Externally publishedYes

Fingerprint

Sierra Leone
Albendazole
Levamisole
Helminths
Necator
Soil
Drug Therapy
Ascaris
Trichuris
Infection
Placebos
Anthelmintics

Keywords

  • Albendazole
  • Anthelmintics
  • Antinematodal Agents
  • Child
  • Feces
  • Follow-Up Studies
  • Helminthiasis
  • Humans
  • Levamisole
  • Parasite Egg Count
  • Prevalence
  • Severity of Illness Index
  • Sierra Leone
  • Soil
  • Students

Cite this

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title = "Comparison of albendazole and levamisole chemotherapy on prevalence and intensity of common soil-transmitted helminth infections in school children, Sierra Leone",
abstract = "A comparison of two studies performed in Sierra Leone on the effect of anthelmintic, chemotherapy, levamisole, albendazole or a placebo in children aged 6 to 10 years on the prevalence and intensity of common soil transmitted helminths (S-THs) infections is presented. In total 501 children were screened, and 394 successfully follow-up. At baseline their overall prevalence and intensity (epg) of Ascaris, Necator and Trichuris were 34{\%} (2,877), 22{\%} (284) and 39{\%} (266) respectively. At baseline there was no significant difference in the intensity of S-THs infections in the different treatment groups but the prevalence of Necator was significantly higher in the levamisole than the albendazole group (p < 0.05). At follow-up both albendazole and levamisole significantly reduced prevalence and intensity of Ascaris and Trichuris. Only albendazole significantly reduced those of Necator. The placebo group had no significant change in prevalence but a significant increase in intensity of all S-THs.",
keywords = "Albendazole, Anthelmintics, Antinematodal Agents, Child, Feces, Follow-Up Studies, Helminthiasis, Humans, Levamisole, Parasite Egg Count, Prevalence, Severity of Illness Index, Sierra Leone, Soil, Students",
author = "Williams, {R A} and Koroma, {M M} and M Hodges",
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TY - JOUR

T1 - Comparison of albendazole and levamisole chemotherapy on prevalence and intensity of common soil-transmitted helminth infections in school children, Sierra Leone

AU - Williams, R A

AU - Koroma, M M

AU - Hodges, M

PY - 1997/7/1

Y1 - 1997/7/1

N2 - A comparison of two studies performed in Sierra Leone on the effect of anthelmintic, chemotherapy, levamisole, albendazole or a placebo in children aged 6 to 10 years on the prevalence and intensity of common soil transmitted helminths (S-THs) infections is presented. In total 501 children were screened, and 394 successfully follow-up. At baseline their overall prevalence and intensity (epg) of Ascaris, Necator and Trichuris were 34% (2,877), 22% (284) and 39% (266) respectively. At baseline there was no significant difference in the intensity of S-THs infections in the different treatment groups but the prevalence of Necator was significantly higher in the levamisole than the albendazole group (p < 0.05). At follow-up both albendazole and levamisole significantly reduced prevalence and intensity of Ascaris and Trichuris. Only albendazole significantly reduced those of Necator. The placebo group had no significant change in prevalence but a significant increase in intensity of all S-THs.

AB - A comparison of two studies performed in Sierra Leone on the effect of anthelmintic, chemotherapy, levamisole, albendazole or a placebo in children aged 6 to 10 years on the prevalence and intensity of common soil transmitted helminths (S-THs) infections is presented. In total 501 children were screened, and 394 successfully follow-up. At baseline their overall prevalence and intensity (epg) of Ascaris, Necator and Trichuris were 34% (2,877), 22% (284) and 39% (266) respectively. At baseline there was no significant difference in the intensity of S-THs infections in the different treatment groups but the prevalence of Necator was significantly higher in the levamisole than the albendazole group (p < 0.05). At follow-up both albendazole and levamisole significantly reduced prevalence and intensity of Ascaris and Trichuris. Only albendazole significantly reduced those of Necator. The placebo group had no significant change in prevalence but a significant increase in intensity of all S-THs.

KW - Albendazole

KW - Anthelmintics

KW - Antinematodal Agents

KW - Child

KW - Feces

KW - Follow-Up Studies

KW - Helminthiasis

KW - Humans

KW - Levamisole

KW - Parasite Egg Count

KW - Prevalence

KW - Severity of Illness Index

KW - Sierra Leone

KW - Soil

KW - Students

M3 - Article

VL - 16

SP - 179

EP - 183

JO - West African Journal of Medicine

JF - West African Journal of Medicine

SN - 0189-160X

IS - 3

ER -