Comparison of albendazole and levamisole chemotherapy on prevalence and intensity of common soil-transmitted helminth infections in school children, Sierra Leone

R A Williams, M M Koroma, M Hodges

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11 Citations (Scopus)

Abstract

A comparison of two studies performed in Sierra Leone on the effect of anthelmintic, chemotherapy, levamisole, albendazole or a placebo in children aged 6 to 10 years on the prevalence and intensity of common soil transmitted helminths (S-THs) infections is presented. In total 501 children were screened, and 394 successfully follow-up. At baseline their overall prevalence and intensity (epg) of Ascaris, Necator and Trichuris were 34% (2,877), 22% (284) and 39% (266) respectively. At baseline there was no significant difference in the intensity of S-THs infections in the different treatment groups but the prevalence of Necator was significantly higher in the levamisole than the albendazole group (p < 0.05). At follow-up both albendazole and levamisole significantly reduced prevalence and intensity of Ascaris and Trichuris. Only albendazole significantly reduced those of Necator. The placebo group had no significant change in prevalence but a significant increase in intensity of all S-THs.

Original languageEnglish
Pages (from-to)179-83
Number of pages5
JournalWest African Journal of Medicine
Volume16
Issue number3
Publication statusPublished - 1 Jul 1997
Externally publishedYes

Keywords

  • Albendazole
  • Anthelmintics
  • Antinematodal Agents
  • Child
  • Feces
  • Follow-Up Studies
  • Helminthiasis
  • Humans
  • Levamisole
  • Parasite Egg Count
  • Prevalence
  • Severity of Illness Index
  • Sierra Leone
  • Soil
  • Students

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