Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy

Shamim Ahmad, Parminder Singh Otaal, Taranjit Singh Rai, Ajay Bahl, Uma Nahar Saikia, Rohit K Manoj, M Thungapathra, Kewal K Talwar, Madhu Khullar

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9 Citations (Scopus)

Abstract

BACKGROUND: Increased levels of TNF-alpha, IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients.

METHODS AND RESULTS: Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-alpha, IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05).

CONCLUSION: Circulating TNF-alpha, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers.

Original languageEnglish
Pages (from-to)139-45
Number of pages7
JournalMolecular and Cellular Biochemistry
Volume324
Issue number1-2
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

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Keywords

  • Adult
  • Biomarkers
  • Cardiomyopathy, Dilated
  • Case-Control Studies
  • Cytokine Receptor gp130
  • Cytokines
  • Female
  • Humans
  • Inflammation
  • Interleukin-6
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain
  • Peptide Fragments
  • Prognosis
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • Tumor Necrosis Factor-alpha
  • Ventricular Function, Left
  • Young Adult

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