Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy

Shamim Ahmad, Parminder Singh Otaal, Taranjit Singh Rai, Ajay Bahl, Uma Nahar Saikia, Rohit K Manoj, M Thungapathra, Kewal K Talwar, Madhu Khullar

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Increased levels of TNF-alpha, IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients.

METHODS AND RESULTS: Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-alpha, IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05).

CONCLUSION: Circulating TNF-alpha, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers.

Original languageEnglish
Pages (from-to)139-45
Number of pages7
JournalMolecular and Cellular Biochemistry
Volume324
Issue number1-2
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

Fingerprint

Brain Natriuretic Peptide
Dilated Cardiomyopathy
Left Ventricular Function
Cytokines
Recovery
Interleukin-6
Tumor Necrosis Factor-alpha
Stroke Volume
Receptors, Tumor Necrosis Factor, Type I
Recovery of Function
Biomarkers
Healthy Volunteers
pro-brain natriuretic peptide (1-76)
Control Groups

Keywords

  • Adult
  • Biomarkers
  • Cardiomyopathy, Dilated
  • Case-Control Studies
  • Cytokine Receptor gp130
  • Cytokines
  • Female
  • Humans
  • Inflammation
  • Interleukin-6
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain
  • Peptide Fragments
  • Prognosis
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • Tumor Necrosis Factor-alpha
  • Ventricular Function, Left
  • Young Adult

Cite this

Ahmad, Shamim ; Otaal, Parminder Singh ; Rai, Taranjit Singh ; Bahl, Ajay ; Saikia, Uma Nahar ; Manoj, Rohit K ; Thungapathra, M ; Talwar, Kewal K ; Khullar, Madhu. / Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy. In: Molecular and Cellular Biochemistry. 2009 ; Vol. 324, No. 1-2. pp. 139-45.
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Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy. / Ahmad, Shamim; Otaal, Parminder Singh; Rai, Taranjit Singh; Bahl, Ajay; Saikia, Uma Nahar; Manoj, Rohit K; Thungapathra, M; Talwar, Kewal K; Khullar, Madhu.

In: Molecular and Cellular Biochemistry, Vol. 324, No. 1-2, 04.2009, p. 139-45.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy

AU - Ahmad, Shamim

AU - Otaal, Parminder Singh

AU - Rai, Taranjit Singh

AU - Bahl, Ajay

AU - Saikia, Uma Nahar

AU - Manoj, Rohit K

AU - Thungapathra, M

AU - Talwar, Kewal K

AU - Khullar, Madhu

PY - 2009/4

Y1 - 2009/4

N2 - BACKGROUND: Increased levels of TNF-alpha, IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients.METHODS AND RESULTS: Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-alpha, IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05).CONCLUSION: Circulating TNF-alpha, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers.

AB - BACKGROUND: Increased levels of TNF-alpha, IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients.METHODS AND RESULTS: Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-alpha, IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05).CONCLUSION: Circulating TNF-alpha, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers.

KW - Adult

KW - Biomarkers

KW - Cardiomyopathy, Dilated

KW - Case-Control Studies

KW - Cytokine Receptor gp130

KW - Cytokines

KW - Female

KW - Humans

KW - Inflammation

KW - Interleukin-6

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain

KW - Peptide Fragments

KW - Prognosis

KW - Receptors, Tumor Necrosis Factor, Type I

KW - Receptors, Tumor Necrosis Factor, Type II

KW - Tumor Necrosis Factor-alpha

KW - Ventricular Function, Left

KW - Young Adult

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DO - 10.1007/s11010-008-9992-1

M3 - Article

VL - 324

SP - 139

EP - 145

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 1-2

ER -