Changes in coronary artery disease risk factors following intermittent hypoxic training

D.M. Bailey, J. Baker, M. Richards, D. Heusch, R. Ponting, T. Ashton, B. Davies

Research output: Contribution to journalMeeting Abstract


The aim of this study was to investigate the effects of hypoxic training on selected risk factors. Thirty two male subjects were randomly assigned to either a normoxic (N, n=14) or hypoxic (H, n=18) training group which involved 4 weeks of cycling in normobaric normoxia (F1O2=20.9%) or normobaric hypoxia (F1O2=16.0%) 3 times per week for 20-30 minutes at 70-85% of maximum heart rate. Immediately prior to (PRE) and 4 days following training (POST), each subject provided an overnight fasted venous blood sample and performed a V̇O2max test in normobaric normoxia. Dietary composition and caloric intake did not change during PRE and POST testing. Serum concentrations of cholesterol, HDL, LDL and non-esterified fatty acids decreased following both N and H training (P<0.05-P<0.001 v PRE, NS between groups). Apolipoproteins A1 and B decreased following N training only (P<0.001). Whilst serum concentrations of vitamin B12 and red cell folate remained stable, plasma total homocysteine increased by 10% (P<0.05) and decreased by 11% following N and H training respectively. V̇O2max increased by 0.47±0.77 L.min−1 (P<0.05) and the rate pressure product decreased by 3±6% (P<0.05) due to a 10±9 mmHg decrease in maximum systolic blood pressure (P<0.001) following H training only. In summary, these data highlight the synergistic effects of physical exercise and intermittent hypoxia which resulted in marked changes in an individual's health and fitness profile.
Original languageEnglish
Pages (from-to)S182-S182
Number of pages1
JournalMedicine & Science in Sports & Exercise
Issue numberSupplement 5
Publication statusPublished - May 1999
Externally publishedYes


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